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Colorectal Cancer Detected by 1H-NMR Spectroscopy

NCT02364154 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 100

Last updated 2018-08-21

No results posted yet for this study

Summary

The hypothesis of the present study is that metabolic phenotyping of blood plasma allows to (i) discriminate between colorectal cancer patients and control subjects and (ii) identify new biomarkers for colorectal cancer. In order to test this hypothesis, the investigators will apply proton nuclear magnetic resonance (1H-NMR) spectroscopy to perform metabolic phenotyping of blood plasma in 50 colorectal cancer patients and 50 control subjects. Multivariate statistics will be performed to assess the discriminative power of the applied methodology in distinguishing between both groups and to identify metabolites with potential as biomarkers for colorectal cancer.

Conditions

Interventions

OTHER

Control group-Blood sampling

Determine the metabolic phenotype of blood plasma by NMR spectroscopy

OTHER

Blood sampling

determine amount and type of free circulating miRNA in blood plasma

Sponsors & Collaborators

  • Ziekenhuis Oost-Limburg

    collaborator OTHER

  • Hasselt University

    lead OTHER

Principal Investigators

  • Michiel thomeer, prof. dr. · Ziekenhuis Oost-Limburg, Hasselt University

  • Liesbet Mesotten, prof. dr. · Ziekenhuis Oost-Limburg, Hasselt University

  • Philip Caenepeel, prof. dr. · Ziekenhuis Oost-Limburg, Hasselt University

  • Peter Adriaensens, prof. dr. · Hasselt University

  • Kirsten Stinkens, dr. · Hasselt University

  • Evelyne Louis, PhD student · Hasselt University

  • Robby Louis, student · Hasselt University

Eligibility

Min Age
40 Years
Max Age
90 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2014-12-31
Primary Completion
2015-06-30
Completion
2015-09-30

Countries

  • Belgium

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02364154 on ClinicalTrials.gov