Atherosclerotic Plaque Characteristics Associated With a Progression Rate of the Plaque in Carotids and a Risk of Stroke

Summary

Atherosclerosis is the most common cause of stroke. The aims of the project are to compare the visual and digital analysis of sonographic images of atherosclerotic plaque in carotids in vivo, in vitro and with a histological composition of the plaque obtained from patients indicated to carotid endarterectomy, to compare the characteristics of symptomatic and asymptomatic atherosclerotic plaques and, subsequently to verify a hypothesis that ultrasound can identify the sonographic plaque characteristics associated with an increased risk of plaque progression and of ischemic stroke (unstable plaque) in patients with carotid atherosclerosis. Identifying of the sonographic characteristics of unstable plaque will allow to improve indication criteria for carotid endarterectomy or stenting and also potential changing of a drug therapy in patients with unstable plaque in the future. Cost efficiency and availability of duplex ultrasound equipment may enable to improve diagnosis of unstable plaque using this new plaque characteristics evaluation in the majority of patients with carotid plaques.

Conditions

• Carotid Artery Plaque

Sponsors & Collaborators

• General Teaching Hospital, Prague

  collaborator OTHER

• Charles University, Czech Republic

  collaborator OTHER

• Palacky University

  collaborator OTHER

• Military University Hospital, Prague

  collaborator OTHER

• University of Ostrava

  collaborator OTHER

• Masaryk Hospital Usti nad Labem

  collaborator OTHER

• University Hospital Hradec Kralove

  collaborator OTHER

• Na Homolce Hospital

  collaborator OTHER

• University Hospital Olomouc

  collaborator OTHER

• University Hospital Ostrava

  lead OTHER

Principal Investigators

• David Skoloudík, MD, Prof · University Hospital Ostrava

Eligibility

Min Age

30 Years

Max Age

90 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2015-04-01

Primary Completion

2026-01-01

Completion

2026-06-01

Countries

• Czechia

Study Locations