Pacritinib in Patients With Endothelial Growth Factor (EGFR) Mutant Non-small Cell Lung Cancer (NSCLC) After EGFR Tyrosine Kinase Inhibitor (TKI)
NCT02342353 · Status: TERMINATED · Phase: PHASE1 · Type: INTERVENTIONAL · Enrollment: 8
Last updated 2018-02-27
Summary
The goal of the study is to find the best dose of pacritinib when given in combination with erlotinib.
Conditions
- Non-Small Cell Lung Cancer
- Nonsmall Cell Lung Cancer
- Carcinoma, Non-Small-Cell Lung
Interventions
- DRUG
-
Pacritinib
- DRUG
-
Erlotinib
Sponsors & Collaborators
-
Washington University School of Medicine
lead OTHER
Principal Investigators
-
Daniel Morgensztern, M.D. · Washington University School of Medicine
Study Design
- Allocation
- NON_RANDOMIZED
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- PARALLEL
Eligibility
- Min Age
- 18 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2015-05-18
- Primary Completion
- 2018-02-06
- Completion
- 2018-02-06
- FDA Drug
- Yes
Countries
- United States
Study Locations
More Related Trials
-
A Phase 1b/2 Study of Safety and Efficacy of Rociletinib in Combination With MPDL3280A in Patients With Advanced or Metastatic EGFR-mutant NSCLC
NCT02630186 ·Status: TERMINATED ·Phase: PHASE1/PHASE2
-
Anti-angiogenesis Combine With EGFR-TKI in Advanced Non-squamous Non Small Cell Lung Cancer
NCT03461185 ·Status: UNKNOWN ·Phase: PHASE2
-
Retrospective Study in Non Small Cell Lung Cancer (NSCLC) With Epidermal Growth Factor Receptor (EGFR)
NCT02293733 ·Status: COMPLETED
-
Induction Therapy With Intercalated Tyrosine Kinase Inhibitor (TKI) and Chemotherapy in NSCLC With Activating Epidermal Growth Factor Receptor (EGFR) Mutation in Stages II-IIIB
NCT02326285 ·Status: TERMINATED ·Phase: PHASE2/PHASE3
-
A Multicenter Randomized Phase III Study Comparing Second-line Treatment With Chemotherapy Associated or Not to Erlotinib in NSCLC Patients With Secondary Resistance to TKI-EGFR
NCT02178397 ·Status: TERMINATED ·Phase: PHASE3
-
Phase I/II Study of PLB1004 Combined With Platinum-based Doublet Chemotherapy in Patients With EGFR Mutation-positive
NCT07063329 ·Status: NOT_YET_RECRUITING ·Phase: PHASE1/PHASE2
-
Erlotinib Therapy and Subsequent Development of Mechanisms of Secondary Resistance in Patients With NSCLC
NCT00997334 ·Status: COMPLETED ·Phase: PHASE2
-
Erlotinib Hydrochloride and Onalespib Lactate in Treating Patients With Recurrent or Metastatic EGFR-Mutant Non-small Cell Lung Cancer
NCT02535338 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
Concurrent EGFR-TKIs and Thoracic Radiation Therapy in Active EGFR Mutation for 1st Line Treatment of Stage IV NSCLC
NCT02353741 ·Status: TERMINATED ·Phase: PHASE2
-
Study of Apatinib as 3rd/4th Line Treatment in Patients With Advanced Non-Squamous Non-small Cell Lung Cancer Harboring Wild-type Epidermal Growth Factor Receptor (EGFR)
NCT02332512 ·Status: UNKNOWN ·Phase: PHASE3
-
Itacitinib in Combination With Erlotinib in Non Small Cell Lung Cancer Patients With Epidermal Growth Factor Receptor (EGFR) Activating Mutations
NCT02355431 ·Status: WITHDRAWN ·Phase: PHASE2
-
HERTHENA-Lung02: A Study of Patritumab Deruxtecan Versus Platinum-based Chemotherapy in Metastatic or Locally Advanced EGFRm NSCLC After Failure of EGFR TKI Therapy
NCT05338970 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE3
-
De Novo Resistance to Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitors
NCT01697163 ·Status: UNKNOWN
-
Rociletinib Genomic Landscape in Non-small Cell Lung Cancer (NSCLC)
NCT02705339 ·Status: WITHDRAWN ·Phase: PHASE2
-
A Study of EGF816 and Gefitinib in TKI-naïve EGFR-mutant Non-Small Cell Lung Cancer
NCT03292133 ·Status: TERMINATED ·Phase: PHASE2
-
A Study of Famitinib in Combination With HS-10296 in Patients With EGFR-mutant NSCLC
NCT03904823 ·Status: UNKNOWN ·Phase: PHASE2
-
Hydroxychloroquine With or Without Erlotinib in Advanced Non-small Cell Lung Cancer (NSCLC)
NCT01026844 ·Status: TERMINATED ·Phase: PHASE1
-
Study of EGFR TKI in Patients With Advanced NSCLC Harbouring EGFR Mutations
NCT06062823 ·Status: RECRUITING ·Phase: PHASE2
-
Study of Patritumab in Combination With Erlotinib in Subjects With Locally Advanced or Metastatic Non-Small-Cell Lung Cancer (NSCLC). (HER3-Lung)
NCT02134015 ·Status: TERMINATED ·Phase: PHASE3
-
A Study of ASP2215 in Combination With Erlotinib in Subjects With Epidermal Growth Factor Receptor (EGFR) Activating Mutation-Positive (EGFRm+) Advanced Non-Small-Cell Lung Cancer (NSCLC) Who Have Acquired Resistance to an EGFR Tyrosine Kinase Inhibitor (TKI)
NCT02495233 ·Status: TERMINATED ·Phase: PHASE1/PHASE2
-
Phase 1/2 Study of the Safety and Efficacy of Rociletinib in Combination With Trametinib in Patients With mEGFR-positive Advanced or Metastatic Non-small Cell Lung Cancer
NCT02580708 ·Status: TERMINATED ·Phase: PHASE1/PHASE2
-
AZD9291 Versus Gefitinib or Erlotinib in Patients With Locally Advanced or Metastatic Non-small Cell Lung Cancer
NCT02296125 ·Status: COMPLETED ·Phase: PHASE3
-
Trilaciclib in Patients Receiving Sacituzumab Tirumotecan for EGFR-mutated, Advanced Non-Small Cell Lung Cancer (NSCLC)
NCT06992739 ·Status: RECRUITING ·Phase: PHASE2
-
Trial Of CP-751, 871 And Erlotinib In Refractory Lung Cancer
NCT00673049 ·Status: TERMINATED ·Phase: PHASE3
-
A Study of Poziotinib in Previously Treated Participants With Locally Advanced or Metastatic NSCLC Harboring HER2 Exon 20 Mutations
NCT05378763 ·Status: SUSPENDED ·Phase: PHASE3