Structured Evaluation of adRENal Tumors Discovered Incidentally - Prospectively Investigating the Testing Yield

Summary

Standard diagnostic work-up for adrenal incidentalomas (AI) consists of periodical biochemical analysis and CT-scanning in case the initial work-up does not demonstrate the presence of hormonal hypersecretion or adrenocortical carcinoma (ACC), respectively. The overall aim of this study is to improve the cost-effectiveness of the diagnostic strategy for AI. Cost-effectiveness of urine steroid profiling (USP) will be compared to the standard diagnostic strategy of repeated CT-imaging.

Conditions

• Adrenal Incidentaloma
• Adrenocortical Carcinoma

Sponsors & Collaborators

• Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)

  collaborator OTHER

• Amsterdam UMC, location VUmc

  collaborator OTHER

• Radboud University Medical Center

  collaborator OTHER

• Leiden University Medical Center

  collaborator OTHER

• Maastricht University Medical Center

  collaborator OTHER

• UMC Utrecht

  collaborator OTHER

• Erasmus Medical Center

  collaborator OTHER

• Martini Hospital Groningen

  collaborator OTHER

• Canisius-Wilhelmina Hospital

  collaborator OTHER

• Diakonessenhuis, Utrecht

  collaborator OTHER

• Isala

  collaborator OTHER

• Haga Hospital

  collaborator OTHER

• St. Antonius Hospital

  collaborator OTHER

• Kennemer Gasthuis

  collaborator OTHER

• Maxima Medical Center

  collaborator OTHER

• Medical Center Alkmaar

  collaborator OTHER

• Frisius Medisch Centrum

  collaborator OTHER

• Meander Medical Center

  collaborator OTHER

• Medisch Spectrum Twente

  collaborator OTHER

• Onze Lieve Vrouwe Gasthuis

  collaborator OTHER

• Rijnstate Hospital

  collaborator OTHER

• Elisabeth-TweeSteden Ziekenhuis

  collaborator OTHER

• Tergooi Hospital

  collaborator OTHER

• Vlietland Ziekenhuis

  collaborator OTHER

• Treant ziekenhuis

  collaborator UNKNOWN

• Flevoziekenhuis

  collaborator OTHER

• University Medical Center Groningen

  lead OTHER

Principal Investigators

• Michiel N Kerstens, MD, PhD · University Medical Center Groningen

• E Buitenwerf, MD · University Medical Center Groningen

• P.H.L.T. Bisschop, MD, PhD · Amsterdam UMC, location VUmc

• E.M.W. Eekhoff, MD, PhD · Free University UMC Amsterdam

• E.P.M. van der Kleij-Corssmit, MD, PhD · Leiden University Medical Center

• R.A. Feelders, MD, PhD · Erasmus Medical Center

• B. Havekes, MD, PhD · Maastricht University Medical Center

• H.J.L.M Timmers, MD, PhD · UMC St Radboud Nijmegen

• G.D. Valk, MD, PhD · UMC Utrecht

• P.H.N. Oomen, MD, PhD · medical center leeuwarden

• K.M. van Tol, MD, PhD · Martini Hospital Groningen

• R.S.M.E. Wouters, MD · Scheper Hospital

• A.A.M. Franken, MD, PhD · Isala

• J.R. Meinardi, MD, PhD · Canisius-Wilhelmina Hospital

• R. GrooteVeldman, MD, PhD · Medisch Spectrum Twente

• P.C. Oldenburg-Ligtenberg, MD, PhD · Meander Medical Center

• A.F. Muller, MD, PhD · Diakonessenhuis, Utrecht

• M.O. van Aken, MD, PhD · Haga Hospital

• W. de Ronde, MD, PhD · Kennemer Gasthuis

• H.R. Haak, MD, PhD · Maxima Medical Center

• S. Simsek, MD, PhD · Medical Center Alkmaar

• I.M.M.J. Wakelkamp, MD, PhD · St. Antonius Hospital

• I.I.L. Berk-Planken, MD, PhD · Vlietland Ziekenhuis

• P.S. van Dam, MD, PhD · Onze Lieve Vrouwe Gasthuis

• H. de Boer, MD, PhD · Rijnstate Hospital

• J.J.J. de Sonnaville, MD, PhD · Tergooi Hospital

• E. Donga, MD · St.Elisabeth Hospital

• N. Smit, MD · Flevoland Hospital

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2015-01-31

Primary Completion

2023-06-30

Completion

2023-06-30

Countries

• Netherlands

Study Locations