Trial Outcomes & Findings for International EXPAND Heart Pivotal Trial (NCT NCT02323321)

NCT ID: NCT02323321

Last Updated: 2025-01-17

Results Overview

A composite endpoint of patient survival at Day-30 post-transplant and absence of severe heart primary graft dysfunction (PGD) (left or right ventricle)) in the first 24 hours post-transplantation.

Recruitment status

COMPLETED

Study phase

NA

Target enrollment

75 participants

Primary outcome timeframe

30 Days

Results posted on

2025-01-17

Participant Flow

Participant milestones

Participant milestones
Measure
OCS Preservation
OCS Preservation and Assessment Preservation of Hearts for Transplantation: Preserving and Assessing Expanded Criteria Donor Hearts for Transplantation
Overall Study
STARTED
75
Overall Study
COMPLETED
62
Overall Study
NOT COMPLETED
13

Reasons for withdrawal

Reasons for withdrawal
Measure
OCS Preservation
OCS Preservation and Assessment Preservation of Hearts for Transplantation: Preserving and Assessing Expanded Criteria Donor Hearts for Transplantation
Overall Study
Re-Transplant
1
Overall Study
Death
12

Baseline Characteristics

International EXPAND Heart Pivotal Trial

Baseline characteristics by cohort

Baseline characteristics by cohort
Measure
OCS Preservation
n=75 Participants
OCS Heart System: The OCS Heart System preserves the heart in a near-physiological, beating state by perfusing the heart with a warmed, donor-blood based perfusate that is supplemented with nutrients and oxygen in a controlled and protected environment
Age, Continuous
55.46 years
STANDARD_DEVIATION 12.556 • n=99 Participants
Sex: Female, Male
Female
14 Participants
n=99 Participants
Sex: Female, Male
Male
61 Participants
n=99 Participants
Ethnicity (NIH/OMB)
Hispanic or Latino
1 Participants
n=99 Participants
Ethnicity (NIH/OMB)
Not Hispanic or Latino
66 Participants
n=99 Participants
Ethnicity (NIH/OMB)
Unknown or Not Reported
8 Participants
n=99 Participants
Race (NIH/OMB)
American Indian or Alaska Native
0 Participants
n=99 Participants
Race (NIH/OMB)
Asian
2 Participants
n=99 Participants
Race (NIH/OMB)
Native Hawaiian or Other Pacific Islander
0 Participants
n=99 Participants
Race (NIH/OMB)
Black or African American
12 Participants
n=99 Participants
Race (NIH/OMB)
White
58 Participants
n=99 Participants
Race (NIH/OMB)
More than one race
2 Participants
n=99 Participants
Race (NIH/OMB)
Unknown or Not Reported
1 Participants
n=99 Participants

PRIMARY outcome

Timeframe: 30 Days

A composite endpoint of patient survival at Day-30 post-transplant and absence of severe heart primary graft dysfunction (PGD) (left or right ventricle)) in the first 24 hours post-transplantation.

Outcome measures

Outcome measures
Measure
OCS Preservation
n=75 Participants
OCS Preservation and Assessment Preservation of Hearts for Transplantation: Preserving and Assessing Expanded Criteria Donor Hearts for Transplantation
Patient Survival at Day-30 Post Transplant and Absence of Severe Primary Heart Graft Dysfunction in the First 24 Hours Post-transplantation
66 Participants

Adverse Events

OCS Preservation

Serious events: 56 serious events
Other events: 0 other events
Deaths: 12 deaths

Serious adverse events

Serious adverse events
Measure
OCS Preservation
n=75 participants at risk
OCS Preservation and Assessment Preservation of Hearts for Transplantation: Preserving and Assessing Expanded Criteria Donor Hearts for Transplantation
Cardiac disorders
Arrhythmia
5.3%
4/75 • Number of events 4 • Per the protocol, all SAEs and heart graft related SAEs will be collected for the first 30 days post-transplant. All-Cause Mortality was assessed for 12 months post-transplant as reported.
Per the protocol, only serious adverse events (SAEs) and Heart Graft-Related SAE's (HGRSAEs) will be captured in this study. Not Serious AEs were not collected, and therefore not reported.
Cardiac disorders
Arrhythmia supraventricular
1.3%
1/75 • Number of events 1 • Per the protocol, all SAEs and heart graft related SAEs will be collected for the first 30 days post-transplant. All-Cause Mortality was assessed for 12 months post-transplant as reported.
Per the protocol, only serious adverse events (SAEs) and Heart Graft-Related SAE's (HGRSAEs) will be captured in this study. Not Serious AEs were not collected, and therefore not reported.
Cardiac disorders
Atrial fibrillation
6.7%
5/75 • Number of events 5 • Per the protocol, all SAEs and heart graft related SAEs will be collected for the first 30 days post-transplant. All-Cause Mortality was assessed for 12 months post-transplant as reported.
Per the protocol, only serious adverse events (SAEs) and Heart Graft-Related SAE's (HGRSAEs) will be captured in this study. Not Serious AEs were not collected, and therefore not reported.
Cardiac disorders
Atrial flutter
1.3%
1/75 • Number of events 1 • Per the protocol, all SAEs and heart graft related SAEs will be collected for the first 30 days post-transplant. All-Cause Mortality was assessed for 12 months post-transplant as reported.
Per the protocol, only serious adverse events (SAEs) and Heart Graft-Related SAE's (HGRSAEs) will be captured in this study. Not Serious AEs were not collected, and therefore not reported.
Cardiac disorders
Atrial tachycardia
1.3%
1/75 • Number of events 1 • Per the protocol, all SAEs and heart graft related SAEs will be collected for the first 30 days post-transplant. All-Cause Mortality was assessed for 12 months post-transplant as reported.
Per the protocol, only serious adverse events (SAEs) and Heart Graft-Related SAE's (HGRSAEs) will be captured in this study. Not Serious AEs were not collected, and therefore not reported.
Cardiac disorders
Atrioventricular block
1.3%
1/75 • Number of events 1 • Per the protocol, all SAEs and heart graft related SAEs will be collected for the first 30 days post-transplant. All-Cause Mortality was assessed for 12 months post-transplant as reported.
Per the protocol, only serious adverse events (SAEs) and Heart Graft-Related SAE's (HGRSAEs) will be captured in this study. Not Serious AEs were not collected, and therefore not reported.
Cardiac disorders
Bradycardia
1.3%
1/75 • Number of events 1 • Per the protocol, all SAEs and heart graft related SAEs will be collected for the first 30 days post-transplant. All-Cause Mortality was assessed for 12 months post-transplant as reported.
Per the protocol, only serious adverse events (SAEs) and Heart Graft-Related SAE's (HGRSAEs) will be captured in this study. Not Serious AEs were not collected, and therefore not reported.
Cardiac disorders
Cardiac failure congestive
5.3%
4/75 • Number of events 4 • Per the protocol, all SAEs and heart graft related SAEs will be collected for the first 30 days post-transplant. All-Cause Mortality was assessed for 12 months post-transplant as reported.
Per the protocol, only serious adverse events (SAEs) and Heart Graft-Related SAE's (HGRSAEs) will be captured in this study. Not Serious AEs were not collected, and therefore not reported.
Cardiac disorders
Cor pulmonale
2.7%
2/75 • Number of events 2 • Per the protocol, all SAEs and heart graft related SAEs will be collected for the first 30 days post-transplant. All-Cause Mortality was assessed for 12 months post-transplant as reported.
Per the protocol, only serious adverse events (SAEs) and Heart Graft-Related SAE's (HGRSAEs) will be captured in this study. Not Serious AEs were not collected, and therefore not reported.
Cardiac disorders
Electromechanical dissociation
1.3%
1/75 • Number of events 1 • Per the protocol, all SAEs and heart graft related SAEs will be collected for the first 30 days post-transplant. All-Cause Mortality was assessed for 12 months post-transplant as reported.
Per the protocol, only serious adverse events (SAEs) and Heart Graft-Related SAE's (HGRSAEs) will be captured in this study. Not Serious AEs were not collected, and therefore not reported.
Cardiac disorders
Left ventricular dysfunction
6.7%
5/75 • Number of events 5 • Per the protocol, all SAEs and heart graft related SAEs will be collected for the first 30 days post-transplant. All-Cause Mortality was assessed for 12 months post-transplant as reported.
Per the protocol, only serious adverse events (SAEs) and Heart Graft-Related SAE's (HGRSAEs) will be captured in this study. Not Serious AEs were not collected, and therefore not reported.
Cardiac disorders
Left ventricular failure
1.3%
1/75 • Number of events 1 • Per the protocol, all SAEs and heart graft related SAEs will be collected for the first 30 days post-transplant. All-Cause Mortality was assessed for 12 months post-transplant as reported.
Per the protocol, only serious adverse events (SAEs) and Heart Graft-Related SAE's (HGRSAEs) will be captured in this study. Not Serious AEs were not collected, and therefore not reported.
Cardiac disorders
Nodal rhythm
1.3%
1/75 • Number of events 1 • Per the protocol, all SAEs and heart graft related SAEs will be collected for the first 30 days post-transplant. All-Cause Mortality was assessed for 12 months post-transplant as reported.
Per the protocol, only serious adverse events (SAEs) and Heart Graft-Related SAE's (HGRSAEs) will be captured in this study. Not Serious AEs were not collected, and therefore not reported.
Cardiac disorders
Pericardial effusion
6.7%
5/75 • Number of events 5 • Per the protocol, all SAEs and heart graft related SAEs will be collected for the first 30 days post-transplant. All-Cause Mortality was assessed for 12 months post-transplant as reported.
Per the protocol, only serious adverse events (SAEs) and Heart Graft-Related SAE's (HGRSAEs) will be captured in this study. Not Serious AEs were not collected, and therefore not reported.
Cardiac disorders
Right ventricular dysfunction
5.3%
4/75 • Number of events 4 • Per the protocol, all SAEs and heart graft related SAEs will be collected for the first 30 days post-transplant. All-Cause Mortality was assessed for 12 months post-transplant as reported.
Per the protocol, only serious adverse events (SAEs) and Heart Graft-Related SAE's (HGRSAEs) will be captured in this study. Not Serious AEs were not collected, and therefore not reported.
Cardiac disorders
Right ventricular failure
1.3%
1/75 • Number of events 1 • Per the protocol, all SAEs and heart graft related SAEs will be collected for the first 30 days post-transplant. All-Cause Mortality was assessed for 12 months post-transplant as reported.
Per the protocol, only serious adverse events (SAEs) and Heart Graft-Related SAE's (HGRSAEs) will be captured in this study. Not Serious AEs were not collected, and therefore not reported.
Congenital, familial and genetic disorders
Atrial septal defect
1.3%
1/75 • Number of events 1 • Per the protocol, all SAEs and heart graft related SAEs will be collected for the first 30 days post-transplant. All-Cause Mortality was assessed for 12 months post-transplant as reported.
Per the protocol, only serious adverse events (SAEs) and Heart Graft-Related SAE's (HGRSAEs) will be captured in this study. Not Serious AEs were not collected, and therefore not reported.
General disorders
Multi-organ failure
1.3%
1/75 • Number of events 1 • Per the protocol, all SAEs and heart graft related SAEs will be collected for the first 30 days post-transplant. All-Cause Mortality was assessed for 12 months post-transplant as reported.
Per the protocol, only serious adverse events (SAEs) and Heart Graft-Related SAE's (HGRSAEs) will be captured in this study. Not Serious AEs were not collected, and therefore not reported.
Hepatobiliary disorders
Hepatic failure
1.3%
1/75 • Number of events 1 • Per the protocol, all SAEs and heart graft related SAEs will be collected for the first 30 days post-transplant. All-Cause Mortality was assessed for 12 months post-transplant as reported.
Per the protocol, only serious adverse events (SAEs) and Heart Graft-Related SAE's (HGRSAEs) will be captured in this study. Not Serious AEs were not collected, and therefore not reported.
Immune system disorders
Heart transplant rejection
16.0%
12/75 • Number of events 12 • Per the protocol, all SAEs and heart graft related SAEs will be collected for the first 30 days post-transplant. All-Cause Mortality was assessed for 12 months post-transplant as reported.
Per the protocol, only serious adverse events (SAEs) and Heart Graft-Related SAE's (HGRSAEs) will be captured in this study. Not Serious AEs were not collected, and therefore not reported.
Infections and infestations
Clostridial infection
1.3%
1/75 • Number of events 1 • Per the protocol, all SAEs and heart graft related SAEs will be collected for the first 30 days post-transplant. All-Cause Mortality was assessed for 12 months post-transplant as reported.
Per the protocol, only serious adverse events (SAEs) and Heart Graft-Related SAE's (HGRSAEs) will be captured in this study. Not Serious AEs were not collected, and therefore not reported.
Infections and infestations
H1N1 influenza
1.3%
1/75 • Number of events 1 • Per the protocol, all SAEs and heart graft related SAEs will be collected for the first 30 days post-transplant. All-Cause Mortality was assessed for 12 months post-transplant as reported.
Per the protocol, only serious adverse events (SAEs) and Heart Graft-Related SAE's (HGRSAEs) will be captured in this study. Not Serious AEs were not collected, and therefore not reported.
Infections and infestations
Pneumonia
1.3%
1/75 • Number of events 1 • Per the protocol, all SAEs and heart graft related SAEs will be collected for the first 30 days post-transplant. All-Cause Mortality was assessed for 12 months post-transplant as reported.
Per the protocol, only serious adverse events (SAEs) and Heart Graft-Related SAE's (HGRSAEs) will be captured in this study. Not Serious AEs were not collected, and therefore not reported.
Infections and infestations
Sepsis
1.3%
1/75 • Number of events 1 • Per the protocol, all SAEs and heart graft related SAEs will be collected for the first 30 days post-transplant. All-Cause Mortality was assessed for 12 months post-transplant as reported.
Per the protocol, only serious adverse events (SAEs) and Heart Graft-Related SAE's (HGRSAEs) will be captured in this study. Not Serious AEs were not collected, and therefore not reported.
Injury, poisoning and procedural complications
Cardiac procedure complication
4.0%
3/75 • Number of events 3 • Per the protocol, all SAEs and heart graft related SAEs will be collected for the first 30 days post-transplant. All-Cause Mortality was assessed for 12 months post-transplant as reported.
Per the protocol, only serious adverse events (SAEs) and Heart Graft-Related SAE's (HGRSAEs) will be captured in this study. Not Serious AEs were not collected, and therefore not reported.
Injury, poisoning and procedural complications
Heart injury
1.3%
1/75 • Number of events 1 • Per the protocol, all SAEs and heart graft related SAEs will be collected for the first 30 days post-transplant. All-Cause Mortality was assessed for 12 months post-transplant as reported.
Per the protocol, only serious adverse events (SAEs) and Heart Graft-Related SAE's (HGRSAEs) will be captured in this study. Not Serious AEs were not collected, and therefore not reported.
Injury, poisoning and procedural complications
Operative haemorrhage
1.3%
1/75 • Number of events 1 • Per the protocol, all SAEs and heart graft related SAEs will be collected for the first 30 days post-transplant. All-Cause Mortality was assessed for 12 months post-transplant as reported.
Per the protocol, only serious adverse events (SAEs) and Heart Graft-Related SAE's (HGRSAEs) will be captured in this study. Not Serious AEs were not collected, and therefore not reported.
Injury, poisoning and procedural complications
Postoperative thoracic procedure complication
1.3%
1/75 • Number of events 1 • Per the protocol, all SAEs and heart graft related SAEs will be collected for the first 30 days post-transplant. All-Cause Mortality was assessed for 12 months post-transplant as reported.
Per the protocol, only serious adverse events (SAEs) and Heart Graft-Related SAE's (HGRSAEs) will be captured in this study. Not Serious AEs were not collected, and therefore not reported.
Injury, poisoning and procedural complications
Procedural complication
2.7%
2/75 • Number of events 2 • Per the protocol, all SAEs and heart graft related SAEs will be collected for the first 30 days post-transplant. All-Cause Mortality was assessed for 12 months post-transplant as reported.
Per the protocol, only serious adverse events (SAEs) and Heart Graft-Related SAE's (HGRSAEs) will be captured in this study. Not Serious AEs were not collected, and therefore not reported.
Injury, poisoning and procedural complications
Rectal laceration postoperative
1.3%
1/75 • Number of events 1 • Per the protocol, all SAEs and heart graft related SAEs will be collected for the first 30 days post-transplant. All-Cause Mortality was assessed for 12 months post-transplant as reported.
Per the protocol, only serious adverse events (SAEs) and Heart Graft-Related SAE's (HGRSAEs) will be captured in this study. Not Serious AEs were not collected, and therefore not reported.
Injury, poisoning and procedural complications
Vascular pseudoaneurysm
1.3%
1/75 • Number of events 1 • Per the protocol, all SAEs and heart graft related SAEs will be collected for the first 30 days post-transplant. All-Cause Mortality was assessed for 12 months post-transplant as reported.
Per the protocol, only serious adverse events (SAEs) and Heart Graft-Related SAE's (HGRSAEs) will be captured in this study. Not Serious AEs were not collected, and therefore not reported.
Metabolism and nutrition disorders
Fluid overload
1.3%
1/75 • Number of events 1 • Per the protocol, all SAEs and heart graft related SAEs will be collected for the first 30 days post-transplant. All-Cause Mortality was assessed for 12 months post-transplant as reported.
Per the protocol, only serious adverse events (SAEs) and Heart Graft-Related SAE's (HGRSAEs) will be captured in this study. Not Serious AEs were not collected, and therefore not reported.
Nervous system disorders
Cerebrovascular accident
4.0%
3/75 • Number of events 3 • Per the protocol, all SAEs and heart graft related SAEs will be collected for the first 30 days post-transplant. All-Cause Mortality was assessed for 12 months post-transplant as reported.
Per the protocol, only serious adverse events (SAEs) and Heart Graft-Related SAE's (HGRSAEs) will be captured in this study. Not Serious AEs were not collected, and therefore not reported.
Nervous system disorders
Convulsion
2.7%
2/75 • Number of events 2 • Per the protocol, all SAEs and heart graft related SAEs will be collected for the first 30 days post-transplant. All-Cause Mortality was assessed for 12 months post-transplant as reported.
Per the protocol, only serious adverse events (SAEs) and Heart Graft-Related SAE's (HGRSAEs) will be captured in this study. Not Serious AEs were not collected, and therefore not reported.
Nervous system disorders
Vocal cord paralysis
1.3%
1/75 • Number of events 1 • Per the protocol, all SAEs and heart graft related SAEs will be collected for the first 30 days post-transplant. All-Cause Mortality was assessed for 12 months post-transplant as reported.
Per the protocol, only serious adverse events (SAEs) and Heart Graft-Related SAE's (HGRSAEs) will be captured in this study. Not Serious AEs were not collected, and therefore not reported.
Psychiatric disorders
Delirium
4.0%
3/75 • Number of events 3 • Per the protocol, all SAEs and heart graft related SAEs will be collected for the first 30 days post-transplant. All-Cause Mortality was assessed for 12 months post-transplant as reported.
Per the protocol, only serious adverse events (SAEs) and Heart Graft-Related SAE's (HGRSAEs) will be captured in this study. Not Serious AEs were not collected, and therefore not reported.
Renal and urinary disorders
Renal failure acute
13.3%
10/75 • Number of events 10 • Per the protocol, all SAEs and heart graft related SAEs will be collected for the first 30 days post-transplant. All-Cause Mortality was assessed for 12 months post-transplant as reported.
Per the protocol, only serious adverse events (SAEs) and Heart Graft-Related SAE's (HGRSAEs) will be captured in this study. Not Serious AEs were not collected, and therefore not reported.
Renal and urinary disorders
Renal impairment
2.7%
2/75 • Number of events 2 • Per the protocol, all SAEs and heart graft related SAEs will be collected for the first 30 days post-transplant. All-Cause Mortality was assessed for 12 months post-transplant as reported.
Per the protocol, only serious adverse events (SAEs) and Heart Graft-Related SAE's (HGRSAEs) will be captured in this study. Not Serious AEs were not collected, and therefore not reported.
Respiratory, thoracic and mediastinal disorders
Acute respiratory distress syndrome
1.3%
1/75 • Number of events 1 • Per the protocol, all SAEs and heart graft related SAEs will be collected for the first 30 days post-transplant. All-Cause Mortality was assessed for 12 months post-transplant as reported.
Per the protocol, only serious adverse events (SAEs) and Heart Graft-Related SAE's (HGRSAEs) will be captured in this study. Not Serious AEs were not collected, and therefore not reported.
Respiratory, thoracic and mediastinal disorders
Acute respiratory failure
2.7%
2/75 • Number of events 2 • Per the protocol, all SAEs and heart graft related SAEs will be collected for the first 30 days post-transplant. All-Cause Mortality was assessed for 12 months post-transplant as reported.
Per the protocol, only serious adverse events (SAEs) and Heart Graft-Related SAE's (HGRSAEs) will be captured in this study. Not Serious AEs were not collected, and therefore not reported.
Respiratory, thoracic and mediastinal disorders
Hydrothorax
1.3%
1/75 • Number of events 1 • Per the protocol, all SAEs and heart graft related SAEs will be collected for the first 30 days post-transplant. All-Cause Mortality was assessed for 12 months post-transplant as reported.
Per the protocol, only serious adverse events (SAEs) and Heart Graft-Related SAE's (HGRSAEs) will be captured in this study. Not Serious AEs were not collected, and therefore not reported.
Respiratory, thoracic and mediastinal disorders
Hypoxia
1.3%
1/75 • Number of events 1 • Per the protocol, all SAEs and heart graft related SAEs will be collected for the first 30 days post-transplant. All-Cause Mortality was assessed for 12 months post-transplant as reported.
Per the protocol, only serious adverse events (SAEs) and Heart Graft-Related SAE's (HGRSAEs) will be captured in this study. Not Serious AEs were not collected, and therefore not reported.
Respiratory, thoracic and mediastinal disorders
Pleural effusion
4.0%
3/75 • Number of events 3 • Per the protocol, all SAEs and heart graft related SAEs will be collected for the first 30 days post-transplant. All-Cause Mortality was assessed for 12 months post-transplant as reported.
Per the protocol, only serious adverse events (SAEs) and Heart Graft-Related SAE's (HGRSAEs) will be captured in this study. Not Serious AEs were not collected, and therefore not reported.
Respiratory, thoracic and mediastinal disorders
Respiratory distress
1.3%
1/75 • Number of events 1 • Per the protocol, all SAEs and heart graft related SAEs will be collected for the first 30 days post-transplant. All-Cause Mortality was assessed for 12 months post-transplant as reported.
Per the protocol, only serious adverse events (SAEs) and Heart Graft-Related SAE's (HGRSAEs) will be captured in this study. Not Serious AEs were not collected, and therefore not reported.
Respiratory, thoracic and mediastinal disorders
Respiratory failure
8.0%
6/75 • Number of events 6 • Per the protocol, all SAEs and heart graft related SAEs will be collected for the first 30 days post-transplant. All-Cause Mortality was assessed for 12 months post-transplant as reported.
Per the protocol, only serious adverse events (SAEs) and Heart Graft-Related SAE's (HGRSAEs) will be captured in this study. Not Serious AEs were not collected, and therefore not reported.
Vascular disorders
Haemorrhage
1.3%
1/75 • Number of events 1 • Per the protocol, all SAEs and heart graft related SAEs will be collected for the first 30 days post-transplant. All-Cause Mortality was assessed for 12 months post-transplant as reported.
Per the protocol, only serious adverse events (SAEs) and Heart Graft-Related SAE's (HGRSAEs) will be captured in this study. Not Serious AEs were not collected, and therefore not reported.
Vascular disorders
Subclavian vein thrombosis
1.3%
1/75 • Number of events 1 • Per the protocol, all SAEs and heart graft related SAEs will be collected for the first 30 days post-transplant. All-Cause Mortality was assessed for 12 months post-transplant as reported.
Per the protocol, only serious adverse events (SAEs) and Heart Graft-Related SAE's (HGRSAEs) will be captured in this study. Not Serious AEs were not collected, and therefore not reported.

Other adverse events

Adverse event data not reported

Additional Information

Laura Damme

TransMedics Inc.

Phone: 9785520900

Results disclosure agreements

  • Principal investigator is a sponsor employee
  • Publication restrictions are in place

Restriction type: OTHER