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Opioids Withdrawal Syndrome in Critically Ill Patients: a Multicenter Prospective Cohort Study

NCT02318290 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 54

Last updated 2016-02-19

No results posted yet for this study

Summary

Critically ill patients who are mechanically ventilated may require prolonged administration of sedatives and analgesics. Their prolonged use has been associated with withdrawal symptoms upon rapid weaning in critically ill patients. These withdrawal symptoms may be associated with adverse clinical outcomes. Although well studied in the paediatric population, little is known about the epidemiology, risk factors and optimal screening methods in adults. Studying this problem is essential as we strive to develop proper weaning strategies.

Methods: Prospective observational two-center study in critically ill adult patients Objectives: 1) Describe the incidence of iatrogenic withdrawal of sedatives and analgesics in critically ill adult patients and 2) Evaluate the performance of screening tools assessing withdrawal that were developed for the paediatric patient in the adult population.

Conditions

  • Substance Withdrawal Syndrome

Interventions

DRUG

Opiates

Mechanically ventilated patients receiving opiates for more than 96 hours will be evaluated for withdrawal symptoms upon weaning of the opiates

Sponsors & Collaborators

  • Centre Integre Universitaire de Sante et Services Sociaux du Nord de l'ile de Montreal

    lead OTHER

Principal Investigators

  • David Williamson, Ph.D. · Hopital du Sacre-Coeur de Montréal

  • Marc Perreaut, Pharm.D. · Montreal General Hospital

  • Anne Julie Frenette, M.Sc. · Hopital du Sacre-Coeur de Montréal

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2015-01-31
Primary Completion
2015-12-31
Completion
2015-12-31

Countries

  • Canada

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02318290 on ClinicalTrials.gov