Regorafenib in Patients With Metastatic Solid Tumors Who Have Progressed After Standard Therapy
NCT02307500 · Status: COMPLETED · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 82
Last updated 2022-09-10
Summary
This is a single arm, single-stage, phase II trial to evaluate the activity of Regorafenib in patients with metastatic solid tumors (pancreatic cancer, ovarian cancer, melanoma, sarcoma, thymoma (type B2 - B3) and thymic carcinoma, who have progressed after standard therapy.
Conditions
- Pancreas Cancer
- Ovarian Cancer
- Melanoma
- Sarcoma
- Thymoma Type B3
- Thymoma Type B2
- Thymic Carcinoma
Interventions
- DRUG
-
oral therapy
Sponsors & Collaborators
-
Istituto Clinico Humanitas
lead OTHER
Principal Investigators
-
Armando Santoro, MD · Istituto Clinico Humanitas
Study Design
- Allocation
- NA
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- SINGLE_GROUP
Eligibility
- Min Age
- 18 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2014-12-31
- Primary Completion
- 2017-12-31
- Completion
- 2020-08-31
Countries
- Italy
Study Locations
More Related Trials
-
Safety and Efficacy Study of a New Chemotherapy Agent to Treat Metastatic Melanoma
NCT00185302 ·Status: COMPLETED ·Phase: PHASE2
-
SB-715992 in Treating Patients With Metastatic or Recurrent Malignant Melanoma
NCT00095953 ·Status: COMPLETED ·Phase: PHASE2
-
Opdualag vs. Cemiplimab/Fianlimab in Relation to the Immunological Response in Tumor and Peripheral Blood in Unresectable or Metastatic Melanoma
NCT07223411 ·Status: RECRUITING
-
A Phase I/II Dose Escalation Study of the Tumor-targeting Human L19-IL2 Monoclonal Antibody-cytokine Fusion Protein in Combination With Dacarbazine for Patients With Metastatic Melanoma
NCT02076646 ·Status: UNKNOWN ·Phase: PHASE1/PHASE2
-
A Clinical Trial of Regorafenib in Patients With Pretreated Advanced Melanoma
NCT05370807 ·Status: UNKNOWN ·Phase: PHASE2
-
An Exploratory Tumor Biopsy-driven Study to Understand the Relationship Between Biomarkers and Clinical Response in Melanoma Patients Receiving REGN2810 (Anti-PD-1)
NCT03002376 ·Status: COMPLETED ·Phase: PHASE1
-
Study to Compare the Efficacy and Safety of Two CC-5013 Dose Regimens in Subjects With Metastatic Malignant Melanoma
NCT00055562 ·Status: COMPLETED ·Phase: PHASE2/PHASE3
-
A Study to Evaluate Safety and Therapeutic Activity of RO6874281 in Combination with Pembrolizumab, in Participants with Advanced or Metastatic Melanoma
NCT03875079 ·Status: COMPLETED ·Phase: PHASE1
-
PEG-Interferon Alfa-2b in Treating Patients With Stage IV Melanoma
NCT00049530 ·Status: COMPLETED ·Phase: PHASE2
-
An Observational Study of BRAF Inhibitors Effectiveness in Patients With Newly Diagnosed Metastatic Melanoma
NCT02143999 ·Status: COMPLETED
-
Study of Molecular Mechanisms Implicated in the Pathogenesis of Melanoma. Role of Exosomes
NCT02310451 ·Status: COMPLETED ·Phase: NA
-
AMT-253 in Patients With Advanced Solid Tumours
NCT06209580 ·Status: RECRUITING ·Phase: PHASE1/PHASE2
-
A Trial to See if the Combination of Fianlimab With Cemiplimab Works Better Than Pembrolizumab for Preventing or Delaying Melanoma From Coming Back After it Has Been Removed With Surgery
NCT05608291 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE3
-
Panobinostat (LBH589) in Patients With Metastatic Melanoma
NCT01065467 ·Status: COMPLETED ·Phase: PHASE1
-
Dose Escalation and Cohort Expansion of Safety and Tolerability Study of Intratumoral rAd.CD40L (ISF35) in Combination of Systemic Pembrolizumab in Patients With Refractory Metastatic Melanoma
NCT02719015 ·Status: WITHDRAWN ·Phase: PHASE1/PHASE2
-
To Evaluate the Efficacy Beyond Progression of Vemurafenib+Cobimetinib Associated With Local Treatment Compared to Second-line Treatment in Patients With BRAFV600+ Metastatic Melanoma in Focal Progression With First-line+Vemurafenib+Cobimetinib.
NCT03514901 ·Status: UNKNOWN ·Phase: PHASE2
-
A Study to Learn About the Study Medicine Called PF-08046031 in Advanced Melanoma and Other Solid Tumors
NCT06799533 ·Status: TERMINATED ·Phase: PHASE1
-
A Trial to Learn if Fianlimab and Cemiplimab Are Safe and Work Better Than Anti-PD1 Alone in Adult Participants With Resectable Stage 3 or 4 Melanoma
NCT06190951 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2
-
Bevacizumab, Dacarbazine and Interferon-Alfa to Treat Metastatic Melanoma
NCT00308607 ·Status: COMPLETED ·Phase: PHASE2
-
Expanded Access Study of Talimogene Laherparepvec for Treatment of Subjects With Unresected Stage IIIB-IVM1c Melanoma
NCT02297529 ·Status: NO_LONGER_AVAILABLE
-
Study to Compare the Efficacy and Safety of CC-5013 vs. Placebo in Subjects With Metastatic Malignant Melanoma.
NCT00057616 ·Status: COMPLETED ·Phase: PHASE3
-
A Phase II Study of Single Agent MEK162 in Patients With Advanced Melanoma
NCT01320085 ·Status: COMPLETED ·Phase: PHASE2
-
Study of MLN2480 in Participants With Relapsed or Refractory Solid Tumors Followed by a Dose Expansion in Participants With Metastatic Melanoma
NCT01425008 ·Status: COMPLETED ·Phase: PHASE1
-
Phase I Safety and Dosimetry Study in Patients With Confirmed Metastatic Melanoma
NCT00747825 ·Status: TERMINATED ·Phase: PHASE1
-
A Clinical Trial of Three Study Medicines (Encorafenib, Binimetinib, and Pembrolizumab) in Patients With Advanced or Metastatic Melanoma
NCT04657991 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE3