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Effect of Smoking Reduction on Endothelial Glucocalyx and Vascular Function

NCT02307045 · Status: UNKNOWN · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 600

Last updated 2020-04-03

No results posted yet for this study

Summary

The integrity of endothelial glucocalyx plays a vital role in vascular permeability and inflammation. Smoking cessation is related with improved vascular function and is a key component of secondary cardiovascular prevention. Pharmacotherapy is a standard component of evidence based smoking cessation treatment. This study was designed to determine the effects medically-aided smoking cessation on glucocalyx thickness and arterial elasticity smoking cessation programs

Conditions

  • Smoking Cessation

Interventions

DRUG

Varenicline

Stimulation of nicotinic receptors by varenicline (Champix) 1,0 mg po

DRUG

nicotine

Nicotine replacement therapy with transdermal patches and/or chewing gums

Sponsors & Collaborators

  • University of Athens

    lead OTHER

Principal Investigators

  • Ignatios Ikonomidis, MD · 2nd Cardiology Department, University of Athens, Greece

  • Kalliroi Kourea, MD · 2nd Cardiology Department, University of Athens, Greece

  • George Pavlidis, MD · 2nd Cardiology Department, University of Athens, Greece

  • Margarita Marinou, MD · 2nd Cardiology Department, University of Athens, Greece

  • John Lekakis, MD · 2nd Cardiology Department, University of Athens, Greece

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2014-12-03
Primary Completion
2020-11-30
Completion
2020-12-31

Countries

  • Greece

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02307045 on ClinicalTrials.gov