Ticagrelor in Patients With ST Elevation Myocardial Infarction Treated With Pharmacological Thrombolysis

Summary

Administration of Ticagrelor in patients with ST elevation myocardial infarction treated with pharmacological thrombolysis

Conditions

• Acute ST Segment Elevation Myocardial Infarction
• Thrombolysis in Myocardial Infarction Flow

Interventions

DRUG

Ticagrelor 180 mg

Ticagrelor, 180 mg as early as possible after the index event and not \>24 h post event followed by 90 mg twice daily for 12 months.

DRUG

Clopidogrel

300 mg clopidogrel as early as possible after the index event and not \> 24h post event, followed by 75mg/day for 12 months. For patients with \> 75 years the recommended load dose is 75 mg instead 300 mg.

Sponsors & Collaborators

• Hospital do Coracao

  lead OTHER

Principal Investigators

• Otavio Berwanger, MD,PhD · Hospital do Coracao

• Helio P Guimaraes, MD,PhD · Hospital do Coracao

• Leopoldo S Piegas, MD,PhD · Hospital do Coracao

• Renato D Lopes, MD,PhD · Duke University

• Jose C Nicolau, MD,PhD · Instituto do Coracao HC-FMUSP

• Francisco A Fonseca, MD,PhD · Universidade Federal de São Paulo

• Jose F Saraiva, MD,PhD · Hospital e Maternidade Celso Pierro

• Carlos Tajer, MD,PhD · Investigación Independiente S.A.

• Stephen Nicholls, MD,PhD · South Australian Health and Medical Research Institute

• Shaun Goodman, MD,PhD · Canadian Heart Research Centre

• Lixin Jiang, MD,PhD · Chinese Academy of Medical Sciences, Fuwai Hospital

• Harvey White, MD,PhD · Auckland City Hospital - Auckland District Health Board

• Germán Malaga, MD,PhD · Universidad Peruana Cayetano Heredia

• Oleg Averkov, MD,PhD · Clinical Hospital #15 Clinical Hospital #15 named after O.M.Filatov, Moscow, Russia

• Alexander Parkhomenko, MD,PhD · Institute of Cardiology - Emergency Cardiology Department

• Christopher Granger, MD,PhD · Duke University

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Model

PARALLEL

Eligibility

Min Age

18 Years

Max Age

75 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2015-08-31

Primary Completion

2017-12-31

Completion

2019-01-31

Countries

• Argentina
• Australia
• Brazil
• Canada
• China
• Colombia
• New Zealand
• Peru
• Russia
• Ukraine

Study Locations