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Investigating the Role of the Polyol Pathway in the Central Nervous System

NCT02272556 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 138

Last updated 2022-08-18

No results posted yet for this study

Summary

Patients will undergo magnetic resonance spectroscopy (MRS) scanning to noninvasively measure intracerebral and plasma metabolite levels at baseline and following 2 and 4 hours of hyperglycemia. Subjects will also undergo a lumbar puncture at a separate occasion to assess cerebrospinal fluid levels of metabolites.

Conditions

Interventions

OTHER

Brain MRS during hyperglycemic clamp

All patients will undergo brain MRS at baseline and following 2 and 4 hours of hyperglycemia using the clamp technique

OTHER

Analysis of Metabolites in cerebrospinal fluid

All patients will have the option to undergo a lumbar puncture for analysis of metabolites in cerebrospinal fluid

Sponsors & Collaborators

Principal Investigators

  • Robert Sherwin, MD · Yale University

Study Design

Allocation
NON_RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
55 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2015-02-28
Primary Completion
2022-05-18
Completion
2022-05-18

Countries

  • United States

Study Locations

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Diseases
Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02272556 on ClinicalTrials.gov