Effect of Cytochrome P 450 3A4 Inhibition by Itraconazole on the Single Oral Dose Pharmacokinetics of Cilobradine
NCT02264041 · Status: COMPLETED · Phase: PHASE1 · Type: INTERVENTIONAL · Enrollment: 25
Last updated 2014-10-15
Summary
Study to investigate the effect of cytochrome P 450 3A4 inhibition by itraconazole on the single dose pharmacokinetics of cilobradine
Conditions
- Healthy
Interventions
- DRUG
-
Cilobradine, low dose
- DRUG
-
Cilobradine, high dose
- DRUG
-
Itraconazole
Sponsors & Collaborators
- lead INDUSTRY
Study Design
- Allocation
- RANDOMIZED
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- CROSSOVER
Eligibility
- Min Age
- 21 Years
- Max Age
- 55 Years
- Sex
- MALE
- Healthy Volunteers
- Yes
Timeline & Regulatory
- Start
- 2004-01-31
- Primary Completion
- 2004-04-30
More Related Trials
-
Study in Postmenopausal Women to Investigate the Drug-drug Interaction (DDI) Between Itraconazole(ITZ) and Orally Administered Vilaprisan; Absolute Bioavailability Using Intravenous Microtracer Dose of [14C]Vilaprisan
NCT02456129 ·Status: COMPLETED ·Phase: PHASE1
-
To Evaluate the Safety and Pharmacokinetic Characteristics of AJU-C714 and C714R in Healthy Adults
NCT06933459 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE1
-
A Crossover Study to Evaluate the Bioavailability of Ibrutinib Suspension and Sprinkle Formulations Compared to Capsules in Healthy Adults
NCT02390609 ·Status: COMPLETED ·Phase: PHASE1
-
Pharmacokinetics Study of Azelaprag (BGE-105) in Older Adult Healthy Volunteers
NCT06141889 ·Status: COMPLETED ·Phase: PHASE1
-
Safety, Tolerability, Pharmacokinetics of Single Rising Oral Doses of BI 1181181 in Healthy Male Volunteers, Including Investigation of the Effect of Food on the Bioavailability of BI 1181181
NCT02044406 ·Status: COMPLETED ·Phase: PHASE1
-
A Two-arm, Open-label, Single-sequence, Multiple-dose, Cross-over Study to Evaluate the Pharmacokinetic Interaction and the Safety of UIC202502 and UIC202505 in Healthy Adult Volunteers
NCT07162441 ·Status: RECRUITING ·Phase: PHASE1
-
Study to Compare Safety and Pharmacokinetics of "CG1801" and "CGL1802" in Healthy Volunteers
NCT03774355 ·Status: COMPLETED ·Phase: PHASE1
-
To Assess Safety, Tolerability and Pharmacokinetics of BI 416970 in Healthy Male Volunteers
NCT02093819 ·Status: COMPLETED ·Phase: PHASE1
-
A Study to Compare the Relative Bioavailability of Two Iberdomide (CC-220) Formulations and to Assess The Effect Of Food on the Drug Levels of Iberdomide in Healthy Adult Participants
NCT05899738 ·Status: COMPLETED ·Phase: PHASE1
-
A Single-Center, Open-Label, Randomized, 3-Treatment Crossover Bioavailability Study of Single Oral Doses of E5501 Old Tablet Formulation Under Fasted Conditions and a New Tablet Formulation Under Fed and Fasted Conditions in Healthy Subjects
NCT01260155 ·Status: COMPLETED ·Phase: PHASE1
-
Safety Tolerability and Pharmacokinetic of BI 411034
NCT01581684 ·Status: COMPLETED ·Phase: PHASE1
-
A Bioavailability and Pharmacokinetic Study of Subcutaneous and Intravenous RO6811135 in Healthy Volunteers
NCT01802853 ·Status: COMPLETED ·Phase: PHASE1
-
A Pharmacokinetic Study to Assess the Influence of Simultaneous CYP3A4 and P-glycoprotein Inhibition on E7080 Pharmacokinetics Following Single Dose Oral Administration of 5 mg E7080 to Healthy Volunteers
NCT02198170 ·Status: COMPLETED ·Phase: PHASE1
-
Study Evaluating Effects of Multiple-Dose Administration of Itraconazole on the Single Dose Pharmacokinetics of Conjugated Estrogens/Bazedoxifene in Non-Obese and Obese Postmenopausal Women
NCT02100553 ·Status: COMPLETED ·Phase: PHASE1
-
Study to Evaluate the Effect of SCY-078 (Ibrexafungerp) on the PK of Pravastatin in Healthy Subjects
NCT04092751 ·Status: COMPLETED ·Phase: PHASE1
-
Pharmacokinetic, Bioavailability, and Safety Study of COV155 Administered in Healthy Subjects Under Fed and Fasted Conditions
NCT02561741 ·Status: COMPLETED ·Phase: PHASE1
-
Pharmacokinetic Study of Alpelisib in Subjects With Hepatic Impairment.
NCT02624557 ·Status: COMPLETED ·Phase: PHASE1
-
Investigation of Pharmacokinetics of BIBX 245 CL and Safety in Healthy Subjects
NCT02264197 ·Status: COMPLETED ·Phase: PHASE1
-
A Pharmacodynamic and Pharmacokinetic Study of RO4917838 in Healthy Volunteers
NCT01543529 ·Status: COMPLETED ·Phase: PHASE1
-
A Study to Assess the Pharmacokinetics of CC-90001 in Subjects With Mild, Moderate, and Severe Hepatic Impairment Compared With Healthy Subjects
NCT03742882 ·Status: COMPLETED ·Phase: PHASE1
-
Pharmacokinetics, Safety and Tolerability of BIIL 284 BS in Patients With Hepatic Impairment in Comparison to Healthy Volunteers
NCT02265627 ·Status: COMPLETED ·Phase: PHASE1
-
A Study in Healthy People to Test How BI 1015550 is Taken up in the Body When Given With or Without Food
NCT06415045 ·Status: COMPLETED ·Phase: PHASE1
-
Metabolism and Pharmacokinetics of [14C]-BIIL 284 BS in Healthy Volunteers
NCT02266550 ·Status: COMPLETED ·Phase: PHASE1
-
A Phase I Bioavailability and Pharmacokinetic Study of [14C]-Ipatasertib Single Oral and Intravenous Doses in Healthy Male Subjects
NCT02390492 ·Status: COMPLETED ·Phase: PHASE1
-
A Pharmacokinetic And Bioavailability Study of Intravenous Danoprevir in Healthy Volunteers
NCT01654211 ·Status: COMPLETED ·Phase: PHASE1