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Salt and TH-17 in Healthy Human Subjects

NCT02261688 · Status: TERMINATED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 9

Last updated 2021-06-08

No results posted yet for this study

Summary

The overall goal of this study is to evaluate the association between sodium and TH17 cells in human subjects. The subjects will have levels of TH-17 and various hormones measured on low salt diet, low salt diet with intravenous normal saline, and high salt diet.

Conditions

  • Th17 Helper Immune Cells
  • Autoimmunity
  • Salt Intake
  • Sodium Chloride

Interventions

DIETARY_SUPPLEMENT

Low salt diet

Low salt diet, 10mmoL of sodium per day, for 6 days

DIETARY_SUPPLEMENT

Low salt diet + IV normal saline

Low salt diet, 10 mmoL of sodium per day, for 4 days with normal saline infusion x 12 hours per day for 200 mmoL of sodium chloride. Total daily sodium is 210 mmoL/day.

DIETARY_SUPPLEMENT

Liberal salt diet

Liberal salt diet targeting 200 mmoL of sodium per day x 7 days

Sponsors & Collaborators

  • Brigham and Women's Hospital

    lead OTHER

Principal Investigators

  • Gordon Williams, MD · Brigham and Women's Hospital

Study Design

Allocation
NA
Purpose
BASIC_SCIENCE
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Max Age
45 Years
Sex
MALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2014-03-31
Primary Completion
2019-07-31
Completion
2019-08-31

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02261688 on ClinicalTrials.gov