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Using MRI To Detect Soft Tissue Reactions And Implant Integration As Related To Implant Modularity

NCT02255331 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 240

Last updated 2025-06-19

No results posted yet for this study

Summary

Patients with a total hip replacement may require early revision surgery due to an adverse local tissue reaction or bone resorption that occurs due to wear debris released from the implant. MRI provides a non-invasive biomarker for clinicians and surgeons to detect early adverse synovial reactions which may exist in the absence of clinical symptoms, thus imparting essential information for clinical management. This study will address two of the most commons causes of hip implant failure, including adverse local tissue reaction in implants not traditionally associated with adverse tissue reactions, as well as the presence of aseptic loosening and loss of implant-bone integration.

Conditions

  • Complications; Arthroplasty
  • Complications; Arthroplasty, Mechanical

Sponsors & Collaborators

  • Medical College of Wisconsin

    collaborator OTHER

  • Hospital for Special Surgery, New York

    lead OTHER

Principal Investigators

  • Matthew F Koff, PhD · Hospital for Special Surgery, New York

  • Hollis G Potter, MD · Hospital for Special Surgery, New York

Eligibility

Min Age
21 Years
Max Age
95 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2017-09-15
Primary Completion
2026-05-31
Completion
2026-08-31

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02255331 on ClinicalTrials.gov