Molecular Profiling in Tissue Samples From Patients With Cancer Who Are Exceptional Responders to Treatment
NCT02243592 · Status: ACTIVE_NOT_RECRUITING · Type: OBSERVATIONAL · Enrollment: 170
Last updated 2026-04-17
Summary
This pilot research trial studies molecular profiling in tissue samples from patients with cancer who got better with treatment that didn't work for most other patients with the same disease. Studying samples of tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in deoxyribonucleic acid (DNA) and identify biomarkers related to how well patients respond to treatment.
Conditions
- Malignant Neoplasm
Interventions
- OTHER
-
Laboratory Biomarker Analysis
Undergo sequencing and SNP analysis
Sponsors & Collaborators
-
National Cancer Institute (NCI)
lead NIH
Principal Investigators
-
S. P Ivy · National Cancer Institute (NCI)
Eligibility
- Min Age
- 18 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2014-09-24
- Primary Completion
- 2021-03-04
- Completion
- 2027-04-30
Countries
- United States
Study Locations
More Related Trials
-
Molecular Profiling Protocol (SCRI-CA-001)
NCT00530192 ·Status: COMPLETED ·Phase: EARLY_PHASE1
-
An Ancillary Pilot Trial Using Whole Genome Sequencing In Patients With Advance Refractory Cancer
NCT01443390 ·Status: COMPLETED
-
Biomarkers in Stored Tumor Samples From Younger Patients With Liver Cancer
NCT00899002 ·Status: WITHDRAWN
-
Genetic Analysis of Blood and Tissue Samples From Patients With Advanced Cancer, Moonshot Study
NCT03707574 ·Status: COMPLETED
-
Development of a Tumor Molecular Analyses Program and Its Use to Support Treatment Decisions
NCT01457196 ·Status: COMPLETED ·Phase: NA
-
Collection of Tissue Samples for Study of Multidrug Resistance
NCT00880503 ·Status: COMPLETED
-
Molecular Analysis of Thoracic Malignancies
NCT01385722 ·Status: ENROLLING_BY_INVITATION
-
Collection of Blood, Bone Marrow, Tumor, or Tissue Samples From Patients With Cancer to Study Drug Resistance
NCT00026663 ·Status: COMPLETED
-
Development of a Cell Free DNA Assay as a Biomarker for Predicting Early Non-response to Therapy in Metastatic Cancer
NCT03892096 ·Status: COMPLETED
-
Laboratory Assay in Determining Cancer Resistance in Patients With Metastatic Cancer and in Healthy Participants
NCT00899496 ·Status: COMPLETED
-
Circulating Tumor DNA in Predicting Outcomes in Patients With Stage IV Head and Neck Cancer or Stage III-IV Non-small Cell Lung Cancer
NCT02245100 ·Status: COMPLETED
-
Biomarkers in Tumor Tissue Samples From Patients With Peripheral T-cell Lymphoma or Natural Killer Cell Neoplasms
NCT01390597 ·Status: COMPLETED
-
Registry Study for Personalized Cancer Therapy
NCT02508662 ·Status: COMPLETED
-
Study of Previously Collected and Stored Tissue Samples From Patients Previously Enrolled in a Completed National Cancer Institute Clinical Trial
NCT00904514 ·Status: TERMINATED
-
Sentinel™ Trial: A Prospective Study Evaluating the Performance and Clinical Benefit of Personalized ctDNA-based MRD Testing to Detect Recurrence and Monitor Treatment Response in Patients With Solid Tumors
NCT05082701 ·Status: TERMINATED
-
Comprehensive Genomic Analysis in Tissue Samples From Patients With Recurrent or Stage IV Non-small Cell Lung Cancer
NCT02178163 ·Status: RECRUITING ·Phase: NA
-
SWOG-8819 Collecting, Analyzing, and Storing Tissue Samples From Patients With Non-Hodgkin's Lymphoma
NCT00900484 ·Status: COMPLETED
-
Measuring Cell Free DNA During the Course of Treatment for Esophageal Cancer as a Marker of Response and Recurrence
NCT03108885 ·Status: TERMINATED
-
Memory Phenotype and PD-1 Inhibition Response in Oral Cancer
NCT03862066 ·Status: TERMINATED
-
Role of Circulating Tumor DNA (ctDNA) From LIquid Biopsy in Early Stage NSCLC Resected Lung Tumor Investigation
NCT03553550 ·Status: TERMINATED
-
Biomarkers in Predicting Response to Treatment in Patients With Newly Diagnosed Stage III or Stage IV Head and Neck Cancer Treated With Carboplatin, Paclitaxel, and Radiation Therapy
NCT00898430 ·Status: TERMINATED
-
Genomic Profiling in Recommending Treatment for Patients With Metastatic Solid Tumors
NCT02215928 ·Status: RECRUITING
-
Feasibility Study of Genomic Sequencing to Find Potential Targets for Personalized Therapy
NCT01869218 ·Status: COMPLETED
-
NSABP Patient Registry and Biospecimen Profiling Repository
NCT01793805 ·Status: COMPLETED
-
Collection of Retrospective (Archival) Samples and Prospective Collection of Surplus Tissue and Blood Samples
NCT02239575 ·Status: WITHDRAWN