Simplified Rapid Hydration in Preventing CA-AKI Among Patients With Chronic Kidney Disease

Summary

No well-defined protocols exist to guide fluid administration for prevention of contrast-associated acute kidney injury in high risk patients. The investigators will compare long term hydration at routine speed(12h before and after procedure at 1ml/kg/h) with short term hydration at high speed(1h before and 4h after procedure at 3ml/kg/h) to verify our hypothesis that the short term hydration may not be inferior to the long one.

Conditions

• Chronic Kidney Disease

Interventions

OTHER

Standard Hydration

Sodium chloride hydration was set between 12 hours before coronary intervention (before contrast exposure during coronary angiography), continued during procedure, and 12 hours after procedure at 1 ml/kg/h (0.5 ml/kg/h For patients with congestive heart failure, New York Heart Association class\>II, or LVEF \< 35%). For patients weighing more than 80 kg, bolus and infusion rates are limited to calculated values for patients weighing 80 kg

OTHER

Simplified Hydration

Hydration with sodium chloride was set 1 hour before procedure (before contrast exposure during coronary angiography), continued during procedure, and 4 hours after procedure at 3ml/kg/h (1.5ml/kg/h For patients with congestive heart failure, New York Heart Association class\>II, or LVEF \<35%). For patients weighing more than 80 kg, bolus and infusion rates are limited to those calculated for patients weighing 80 kg.

Sponsors & Collaborators

• Peking University First Hospital

  collaborator OTHER

• Fudan University

  collaborator OTHER

• The General Hospital of Northern Theater Command

  collaborator OTHER

• Xiamen Cardiovascular Hospital, Xiamen University

  collaborator OTHER

• First Affiliated Hospital of Guangxi Medical University

  collaborator OTHER

• Sichuan Provincial People's Hospital

  collaborator OTHER

• Wuhan Asia Heart Hospital

  collaborator OTHER

• West China Hospital

  collaborator OTHER

• Jining Medical University

  collaborator OTHER

• The First Affiliated Hospital of Zhengzhou University

  collaborator OTHER

• Fujian Provincial Hospital

  collaborator OTHER

• First Affiliated Hospital, Sun Yat-Sen University

  collaborator OTHER

• Fuling Central Hospital of Chongqing City

  collaborator OTHER

• Second Xiangya Hospital of Central South University

  collaborator OTHER

• People's Hospital of Guangxi Zhuang Autonomous Region

  collaborator OTHER

• Maoming People's Hospital

  collaborator OTHER

• Xijing Hospital

  collaborator OTHER

• Beijing Friendship Hospital

  collaborator OTHER

• Tangshan Gongren Hospital

  collaborator OTHER

• Xuzhou Central Hospital

  collaborator OTHER

• Southern Medical University, China

  collaborator OTHER

• Guangdong Provincial People's Hospital

  lead OTHER

Principal Investigators

• Jiyan Chen, MD · Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital

• Yong Liu, MD · Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital

• Yong Huo, MD · Peking University First Hospital

• Junbo Ge, MD · Fudan University

• Pingyan Chen, MS · Southern Medical University

Study Design

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

NONE

Model

PARALLEL

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2015-04-30

Primary Completion

2021-12-31

Completion

2021-12-31

Countries

• China

Study Locations