Bevacizumab-containing Regimen for Metastatic Colorectal Cancer Failed to Cytotoxic Treatment
NCT02226289 · Status: UNKNOWN · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 46
Last updated 2020-09-02
Summary
Bevacizumab, a humanized monoclonal antibody against vascular endothelial growth factor (VEGF), combined with fluoropyrimidine-based chemotherapy is now the standard first and second-line treatment for metastatic colorectal cancer. The efficacy of bevacizumab with cytotoxic agents in the third-line treatment of patients with mCRC is still unknown.
Conditions
- Neoplasm
- Colorectal Cancer
- Metastatic Neoplasm
Interventions
- DRUG
-
bevacizumab with the latest received cytotoxic regimen
Sponsors & Collaborators
-
Sixth Affiliated Hospital, Sun Yat-sen University
lead OTHER
Principal Investigators
-
Ping Lan, Ph D · Sixth Affiliated Hospital, Sun Yat-sen University
Study Design
- Allocation
- NA
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- SINGLE_GROUP
Eligibility
- Min Age
- 18 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2020-09-30
- Primary Completion
- 2020-12-31
- Completion
- 2020-12-31
Countries
- China
Study Locations
More Related Trials
-
Bevacizumab and Combination Chemotherapy as First-Line Therapy in Treating Patients With Metastatic Colorectal Cancer That Cannot Be Removed By Surgery
NCT00423696 ·Status: COMPLETED ·Phase: PHASE2
-
XELOX +Bev +Tislelizumab for First-line Treatment of MSS/pMMR RAS-mutated mCRC
NCT05970302 ·Status: RECRUITING ·Phase: PHASE2
-
Bevacizumab in Treating Patients Who Have Undergone First-Line Therapy for Metastatic Colorectal Cancer
NCT00544700 ·Status: TERMINATED ·Phase: PHASE3
-
Bevacizumab Plus mFOLFOXIRI as First-line Treatment for Patients With Unresectable Metastatic Colorectal Cancer
NCT04230187 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE3
-
PD-1 Antibody Plus Bevacizumab and CAPOX as First-line Treatment for RAS-mut MSS mCRC
NCT06206096 ·Status: RECRUITING ·Phase: PHASE2
-
Cetuximab and Bevacizumab as First-Line Therapy Followed By Combination Chemotherapy and Bevacizumab With or Without Cetuximab as Second-Line Therapy in Treating Patients With Stage IV Colorectal Cancer
NCT00571740 ·Status: WITHDRAWN ·Phase: PHASE2
-
Second-Line Combination Chemotherapy With or Without Bevacizumab in Treating Patients With Metastatic Colorectal Cancer Who Have Received First-Line Chemotherapy and Bevacizumab
NCT00720512 ·Status: TERMINATED ·Phase: PHASE3
-
Envafolimab Combined With Trifluridine/Tipiracil and Bevacizumab in the Treatment of Refractory mCRC.
NCT06060704 ·Status: RECRUITING ·Phase: PHASE2
-
A Study of 2nd-line FOLFIRI ± Bevacizumab vs. Irinotecan ± Bevacizumab in mCRC
NCT03303495 ·Status: UNKNOWN ·Phase: PHASE3
-
Evaluation of Bevacizumab in Combination With First-Line Chemotherapy in Patients Aged 75 Years of Older With Metastatic Colorectal Adenocarcinoma (Prodige20)
NCT01900717 ·Status: COMPLETED ·Phase: PHASE2
-
A Phase I/II Study of XELOXIRI and Bevacizumab as First-line Treatment in Metastatic Colorectal Cancer
NCT04380103 ·Status: UNKNOWN ·Phase: PHASE1/PHASE2
-
A Phase III Study of 2nd-line XELIRI ± Bevacizumab vs. FOLFIRI ± Bevacizumab in mCRC
NCT01996306 ·Status: COMPLETED ·Phase: PHASE3
-
Phase II Study of Bevacizumab, Capecitabine and Oxaliplatin in Colon Cancer
NCT00378066 ·Status: COMPLETED ·Phase: PHASE2
-
Second-line Standard Treatment Sequential TAS-102 and Bevacizumab Combined With Local Treatment in Advanced Colorectal Cancer
NCT06856187 ·Status: RECRUITING ·Phase: PHASE2
-
Combination Chemotherapy With or Without Bevacizumab Compared With Bevacizumab Alone in Treating Patients With Advanced or Metastatic Colorectal Cancer That Has Been Previously Treated
NCT00025337 ·Status: COMPLETED ·Phase: PHASE3
-
Combination Chemotherapy and Bevacizumab in Treating Patients With Metastatic Colorectal Cancer
NCT00628810 ·Status: COMPLETED ·Phase: PHASE2
-
A Phase 2 Study of SSGJ-707 in Metastatic Colorectal Cancer Patients
NCT06493760 ·Status: RECRUITING ·Phase: PHASE2
-
Clinical Study of Second-line Treatment in Advanced Colorectal Cancer With Chemotherapy With Bevacizumab or Cetuximab
NCT06540326 ·Status: RECRUITING ·Phase: PHASE2
-
Clinical Study of Short-course Radiotherapy Followed by Fruquintinib Plus Sintilimab vs Bevacizumab Plus Capecitabine as First Line Treatment in Advanced mCRC
NCT06195670 ·Status: NOT_YET_RECRUITING ·Phase: PHASE1/PHASE2
-
S-1 and Bevacizumab in Treating Patients With Colorectal Cancer That is Recurrent or Cannot Be Removed by Surgery
NCT00974389 ·Status: UNKNOWN ·Phase: PHASE2
-
Study of Magrolimab Given Together With FOLFIRI/Bevacizumab (BEV) in Participants With Previously Treated Advanced Inoperable Metastatic Colorectal Cancer (mCRC)
NCT05330429 ·Status: TERMINATED ·Phase: PHASE2
-
Post-First Progression Use of Bevacizumab in Metastatic Colorectal Cancer (mCRC)
NCT00862342 ·Status: COMPLETED ·Phase: PHASE2
-
Combination Chemotherapy and Cetuximab or Bevacizumab in Treating Patients With Metastatic Colorectal Cancer
NCT01280643 ·Status: TERMINATED ·Phase: NA
-
SBRT Sequential CapeOX Regimen Combined With Bevacizumab and Sintilimab in First-line Treatment of mCRC
NCT05438108 ·Status: UNKNOWN ·Phase: PHASE2
-
Using Positron Emission Tomography to Evaluate the Effects of Bevacizumab on Intra-tumoral Pharmacokinetics of 5-fluorouracil in Metastatic Colorectal Cancer
NCT00165568 ·Status: COMPLETED ·Phase: PHASE2