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Treatment of Intrabony Periodontal Defects With Enamel Matrix Derivatives and Autogenous Bone Graft

NCT02218515 · Status: COMPLETED · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 30

Last updated 2014-08-18

No results posted yet for this study

Summary

The present study aimed to evaluate the effects of enamel matrix derivatives either alone or combined with autogenous bone graft applied to intrabony defects in chronic periodontitis patients on clinical/radiographic parameters and gingival crevicular fluid transforming growth factor-β1 level and, to compare with open flap debridement. Our hypothesis is to test whether the use of autogenous bone graft and enamel matrix derivative combination in the treatment of intrabony periodontal defects enhance the clinical, radiographic and biochemical parameters in comparison to the use of open flap debridement alone.

Conditions

  • Periodontal Bone Loss
  • Chronic Periodontitis

Interventions

PROCEDURE

Open Flap Debridement

Open Flap Debridement (Control Group)

BIOLOGICAL

EmdogainⓇ(Enamel Matrix Derivative)

Open Flap Debridement+Enamel Matrix Derivative

BIOLOGICAL

EmdogainⓇEnamel Matrix Derivative+Autogenous Bone

Open Flap Debridement+EmdogainⓇ(Enamel Matrix Derivative)+Autogenous Bone

Sponsors & Collaborators

  • Haner Direskeneli, Prof

    lead OTHER

Principal Investigators

  • Ömer Birkan Ağralı, Dr. · Marmara University Faculty of Dentistry, Department of Periodontology

  • Bahar Kuru, Prof. Dr. · Marmara University, Faculty of Dentistry, Department of Periodontology

  • Leyla Kuru, Prof. Dr. · Marmara University, Faculty of Dentistry, Department of Periodontology

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
32 Years
Max Age
57 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2010-09-30
Primary Completion
2012-09-30
Completion
2012-09-30

Countries

  • Turkey (Türkiye)

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02218515 on ClinicalTrials.gov