Comparative Study on Liver Resection Between Harmonic Scalpel Versus Crush-clamping Method

Summary

Blood loss during liver resection significantly associates with short term operative outcome. The median blood loss during partial liver resection is 700-1200ml in high-volume centers. Conventional method (crush-clamp) has been a standard technique for liver transection. Technique advances related to liver transection have contributed to reduction in blood loss. Several studies have showed that Harmonic Scalpel in liver resection is safe and easy to use. A nonrandomized study showed use of the Harmonic Scalpel was associated with decreased operative time, blood loss and transfusion requirement, and an increased incidence of postoperative bile leakage. However, no randomized study has compared the difference between liver resection using traditional technology and harmonic Scalpel. The objective of this prospective randomized study is to compare the safety and efficacy of liver resection using the harmonic scalpel device with the "crush-clamp" technique in respect to blood loss, liver transection time, hepatic hilum clamping time, hospital stay and postoperative complications.

Conditions

• Hepatic Neoplasms

Sponsors & Collaborators

• Hui-Chuan Sun

  lead OTHER

Principal Investigators

• Hui Chuan Sun, Professor · Fudan University

• Jia Fan, Professor · Fudan University

• Jian Zhou, Professor · Fudan University

• Shuang Jian Qiu, Professor · Fudan University

• Guo Ming Shi, Asso. Prof. · Fudan University

• Qing Hai Ye, Professor · Fudan University

• Lu Wang, Professor · Fudan University

• Xiao Wu Huang, Professor · Fudan University

• Ning Ren, Professor · Fudan University

• Jing Xian Yu, Nurse · Fudan University

• Yang Xu, Asso. Prof. · Fudan University

• Ying Hong Shi, Asso. Prof. · Fudan University

• Xiao Ying Wang, Asso. Prof · Fudan University

• Jian Sun, Asso. Prof. · Fudan University

• Zheng Wang, Asso. Prof. · Fudan University

• Yong Sheng Xiao, Asso. Prof. · Fudan University

• Pei Chen, Asso. Prof. · Fudan University

• Cheng Huang, Asso. Prof. · Fudan University

• Ying Hao Shen, Asso. Prof. · Fudan University

Eligibility

Min Age

18 Years

Max Age

80 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2014-05-31

Primary Completion

2015-10-31

Completion

2015-10-31

Countries

• China

Study Locations