Effects of Inhaled Corticosteroids in the Systemic Inflammation Induced by Exercise in Patients With COPD

Summary

Chronic obstructive pulmonary disease (COPD) is characterized by pulmonary and systemic inflammation. The effect of inhaled corticosteroids (IC) on inflammation in COPD is controversial.

Conditions

• Chronic Obstructive Pulmonary Disease

Interventions

DRUG

Fluticasone

Administration of inhaled corticosteroids (fluticasone, 0.5 mg) each 12 hours to 8 of the 16 COPD patients versus placebo.

DRUG

Inhaled Placebo

Sponsors & Collaborators

• Sociedad Española de Neumología y Cirugía Torácica

  collaborator OTHER

• Hospital Son Espases

  collaborator OTHER

• Spanish Research Center for Respiratory Diseases

  collaborator OTHER

• Hospital Clinic of Barcelona

  collaborator OTHER

• Fundació d'investigació Sanitària de les Illes Balears

  collaborator OTHER_GOV

• Hospital Son Llatzer

  lead OTHER

Principal Investigators

• Antonia Fuster, PhD Medicine · Hospital Son Llatzer

• Jaume Sauleda, PhD Medicine · Hospital Son Espases

• Catalina Balaguer, Medicine · Hospital Son Espases

• Bernardí Barceló, PhD Medicine · Hospital Son Espases

• Angel Rios, Nursing · FISIB Fundació Investigació de les Illes Balears

• Amanda Iglesias, Biology · FISIB Fundació Investigació de les Illes Balears

• Aina Noguera, Medicine · Hospital Son Espases

• Bernat Togores, Medicine · Hospital Son Espases

• Alvar Agustí, PhD Medicine · IDIBAPS Hospital Clínic

• Ernest Sala-Llinàs, PhD Medicine · Hospital Son Espases

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Model

PARALLEL

Eligibility

Min Age

58 Years

Max Age

72 Years

Sex

MALE

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2004-02-29

Primary Completion

2009-11-30

Completion

2009-11-30

Countries

• Spain

Study Locations