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Effects of Physical Activity in Psychosis

NCT02205684 · Status: UNKNOWN · Phase: NA · Type: INTERVENTIONAL · Enrollment: 126

Last updated 2018-04-17

No results posted yet for this study

Summary

Physical health problems are common in schizophrenia with a two- to three-fold increased morbidity and mortality rate, resulting in a 20 years reduction in life expectancy. A genetic vulnerability for developing cardiovascular disease has been documented in these patients, and many lifestyle factors also negatively influence physical health. Patients with schizophrenia are likely to smoke, are physically inactive and overweight, suffer from malnutrition due to unhealthy diet, and have reduced cardiorespiratory fitness. Moreover, these patients have increased risk of developing diabetes mellitus type II and metabolic syndrome. These aspects demonstrate the need for multi-disciplinary treatments of patients with schizophrenia and underline the need for addressing their physical health.

Poor physical fitness seems to be associated with exacerbated negative symptoms and increased cognitive dysfunction in patients with schizophrenia. However, evidence on physical activity and its consequences in schizophrenia is scarce. In this randomized controlled trial we investigate the effects of high intensity training in outpatients with schizophrenia on psychotic symptoms and well-being, cognition and cortical structure, tobacco smoking and substance use, in addition to metabolic indices.

Conditions

Interventions

OTHER

Computer game skills training

Playing Nintendo Wii Sports

OTHER

Physical activity

Aerobic High Intensity Training (HIT)

Sponsors & Collaborators

  • Stiftelsen Helse og Rehabilitering

    collaborator OTHER

  • Norwegian Research network in Severe Mental Illness

    collaborator UNKNOWN

  • Sykehuset i Vestfold HF

    lead OTHER

Principal Investigators

  • John A Engh, MD, PhD · Division of Mental Health & Addiction, Vestfold Hospital Trust, Tønsberg, Norway

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
67 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2014-08-31
Primary Completion
2017-10-31
Completion
2019-12-31

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Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02205684 on ClinicalTrials.gov