Study of the Relationship Between Clinical and Paraclinical Markers During Situations of Cachexia and Pre-cachexia in Patients Over 70 Years With Colorectal Surgery

Summary

Cachexia associated with cancer is a grave and most of the time irreversible common situation. It seems independent from the size of the tumor or from its metastatic character. The consequences for the management of the patient are major and exceed widely the frame of the nutrition.

Undernutrition of patients with cancer is described by a decrease of the energy contributions and a loss of muscular and fat mass, leading to a progressive functional deficiency which can go to the cachectic state.

Actually, clinical criteria are proposed allowing to characterize the state of pre-cachexia but it remain too indistinct to allow an early and efficient screening and set up effective measures of prevention of the cachexia, to avoid the loss of muscular tissue and the cast iron of the energy reserves.

It is necessary to have clinical and biological markers with diagnostic aim and forecasts during the situations precedents the appearance of cachexia.

The present study will allow calibrating a longitudinal study, which could confirm the value of measures made for the diagnosis of pre-cachexia.

Conditions

• Colorectal Tumor

Interventions

PROCEDURE

Biopsy of adipose and muscular tissue

OTHER

Blood sampling

OTHER

Calorimetry

OTHER

Impedance measure

Evaluation of physical composition (non-invasive method)

OTHER

Evaluation of nutritional status

Nutritional status will be assessed by using the "Mini Nutritional Assessment" (MNA) questionnaire and a scale that evaluates anorexia

OTHER

Evaluation of physical performance

This will be assessed by using a "tiredness scale" named "Echelle Visuelle Analogique" (EVA) in french

OTHER

Evaluation of muscular strength

Muscular strength will be assessed thanks to the Handgrip Strength Test and the Short Physical Performance Battery (SPPB)

OTHER

Evaluation of emotional status

The emotional status wil be assessed thanks to the Yesavage Geriatric Depression Scale (GDS)

OTHER

Evaluation of functional status

The functional status will be assessed by using the Activity of Daily Life (ADL) questionnaire and the Instrumental Activities of Daily Living (IADL) Questionnaire

Sponsors & Collaborators

• Hospices Civils de Lyon

  lead OTHER

Study Design

Allocation

NA

Purpose

OTHER

Masking

NONE

Model

SINGLE_GROUP

Eligibility

Min Age

70 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2013-10-07

Primary Completion

2018-02-07

Completion

2018-03-07

Countries

• France

Study Locations