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Supernormal Goal for Proximal Femur Fracture

NCT02194101 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 30

Last updated 2014-07-18

No results posted yet for this study

Summary

This is an observational pilot study of supernormal oxygen delivery goal for patients with proximal femoral fracture.

Conditions

  • Femoral Fractures

Interventions

PROCEDURE

Supernormal oxygen delivery goal therapy

A 10% increase in stroke volume (SV) after fluid challenge (5 ml/kg) with Ringer's lactate solution will be deemed positive. Oxygen delivery will be check when fluid challenge becomes negative. If oxygen delivery index (DO2I) can not be greater than 600 mL/m2, then dobutamine will be started at a dose of 2.5 μg/kg/min and increased by the same increment every 20 minutes until the described target is reached or until a maximal dose of 10 μg/kg/min is given. Dobutamine is decreased in dose or discontinued if the heart rate is above 100 beats per minute or shows signs of cardiac ischemia. Blood transfusions will be used to maintain a hemoglobin concentration over 8mg/dL.

Sponsors & Collaborators

  • Guangzhou First People's Hospital

    lead OTHER

Principal Investigators

  • Xiangcai Ruan, MD., PhD. · Guangzhou First Municipal People's Hospital,Guangzhou,Guangdong,China,510180

Eligibility

Min Age
70 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2014-08-31
Primary Completion
2015-04-30
Completion
2015-06-30

Countries

  • China

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02194101 on ClinicalTrials.gov