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Effect of Oral Health Ingredients on the Acquired Salivary Pellicle

NCT02188238 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 10

Last updated 2019-03-07

No results posted yet for this study

Summary

The aim of this study is to help us understand how saliva forms a thin film inside the surfaces of the mouth which is known as the salivary pellicle, and how this film helps to protect our teeth from decay. We know that the thickness and physical properties (viscosity and mechanical strength) of the salivary pellicle influences:-

* How we chew and sense the structure of food in our mouth.
* How we digest the food and extract nutrients from it.
* Protection against tooth decay and infection.

However, studies have only recently established the different proteins within the pellicle. The effects of oral care products (e.g. toothpaste, mouthwash etc.) and ingredients they contain on pellicle formation and removal remain poorly understood. Therefore we need to understand how the formation of the salivary pellicle is controlled by ingredients it comes into contact with such as those from food and oral hygiene products (e.g. toothpaste and mouthwash).

In this study, we are asking volunteers to provide samples of saliva. We will take the saliva samples back to our labs and measure how they form films under different conditions and determine the influence of ingredients from oral hygiene on the film forming properties. We will also measure the protein content of the saliva sample to see how this affects pellicle formation. Eventually, this information together with knowledge from other studies, should lead to the development of more effective oral hygiene products.

Conditions

  • Healthy

Interventions

OTHER

Saliva Sample Collection

Saliva samples will be collected from healthy volunteers recruited locally. Stimulated whole mouth saliva is collected through stimulation by inert gum, and collecting the saliva by gently spitting into a sterile tube.

Sponsors & Collaborators

  • GlaxoSmithKline

    collaborator INDUSTRY

  • Quadram Institute Bioscience

    lead OTHER

Principal Investigators

  • Peter J Wilde, PhD · Quadram Institute Bioscience

Eligibility

Min Age
18 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2014-07-31
Primary Completion
2018-09-30
Completion
2018-12-31

Countries

  • United Kingdom

Study Locations

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Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02188238 on ClinicalTrials.gov