Effect of Gemigliptin on Metabolic Endotoxemia and Lipemia
NCT02186080 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 10
Last updated 2016-04-21
Summary
This is an exploratory study on the metabolic endotoxemia associated with type 2 diabetes. The investigators will measure systemic endotoxin level and lipid level after ingestion of high fat diet to evaluate the effect of gemigliptin, a DPP-4 inhibitor, on metabolic endotoxemia and lipemia induced by high fat diet.
Conditions
Interventions
- DRUG
-
Gemigliptin
- DRUG
Sponsors & Collaborators
-
LG Life Sciences
collaborator INDUSTRY -
Seoul National University Hospital
lead OTHER
Principal Investigators
-
Young Min Cho, MD, PhD · Seoul National University Hospital
Study Design
- Allocation
- RANDOMIZED
- Purpose
- BASIC_SCIENCE
- Masking
- QUADRUPLE
- Model
- CROSSOVER
Eligibility
- Min Age
- 20 Years
- Max Age
- 75 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2014-07-31
- Primary Completion
- 2015-07-31
- Completion
- 2015-07-31
Countries
- South Korea
Study Locations
More Related Trials
-
Trial to Evaluate the Efficacy on Glycemic Variability and Safety of Gemigliptin Compared With Dapagliflozin Added on Metformin Alone or Diabetes Medication Naïve Patient in Type 2 Diabetes Mellitus (Stable II Study)
NCT03202563 ·Status: COMPLETED ·Phase: PHASE4
-
Efficacy and Safety of Gemigliptin 50mg qd Added in Patients With Type 2 Diabetes Inadequately Controlled on Glimepiride and Metformin
NCT01990469 ·Status: COMPLETED ·Phase: PHASE3
-
Effects of Gemigliptin Versus Sitagliptin or Glimepiride With Metformin on Glucose Variability(MAGE, Glucose SD) Patients With Type 2 DM(STABLE Study)
NCT01890629 ·Status: COMPLETED ·Phase: PHASE4
-
An Ascending Dose, Single/Multiple Dosing, Food Effect Clinical Trial to Evaluate Pharmacokinetics, Safety and Tolerability in Healthy Subjects After Oral Administration of Gemigliptin (Phase I)
NCT03864432 ·Status: COMPLETED ·Phase: PHASE1
-
Phase III Trial to Evaluate the Efficacy and Safety of Initial Combination Therapy With Gemigliptin 50mg q.d and Metformin q.d
NCT01787396 ·Status: COMPLETED ·Phase: PHASE3
-
Phase III Trial to Evaluate the Efficacy and Safety of Gemigliptin 50mg qd Added to Ongoing Glimepiride as Fix-dose Combination in Patients With Type 2 Diabetes
NCT02089126 ·Status: UNKNOWN ·Phase: PHASE3
-
An Observational Study to Evaluate Cardiovascular Outcomes of T2DM PatientsTreated With Gemigliptin
NCT02290301 ·Status: COMPLETED
-
Antidiabetic Effects on Intrahepatic Fat
NCT03068065 ·Status: COMPLETED ·Phase: PHASE4
-
A Clinical Trial to Investigate Safety/Tolerability and Pharmacokinetics of DA-1229_01 Compared to Co-administration of Evogliptin 5 mg and Metformin XR 1000 mg, and to Evaluate the Effect of Food on the Pharmacokinetics of DA-1229_01 in Healthy Male Volunteers
NCT02167061 ·Status: COMPLETED ·Phase: PHASE1
-
Food-Effect Bioavailability Study of FDC(Gemigliptin/Metformin HCl Sustained Release) 50/1000mg(25/500mg x 2tablets)
NCT01747083 ·Status: COMPLETED ·Phase: PHASE1
-
BE Study of the Combinations of Gemigliptin 50mg and Metformin HCl Extended Release 1000mg in Comparison to Each Component Administered Alone
NCT01662674 ·Status: COMPLETED ·Phase: PHASE1
-
Drug-Drug Interaction Study of Mitiglinide and Gemfibrozil
NCT00566865 ·Status: COMPLETED ·Phase: PHASE1
-
BE Study of the Combinations of Gemigliptin 50mg and Metformin HCl Extended Release 2000mg in Comparison to Each Component Administered Alone
NCT02670018 ·Status: UNKNOWN ·Phase: PHASE1
-
A Clinical Study to See How the Body Handles and How Safe a Combination Tablet of Gemigliptin, Dapagliflozin, and Metformin 50/10/1000mg is Compared to Taking Gemigliptin 50mg Separately With Dapagliflozin/Metformin 10/1000mg in Healthy Adults After a Meal
NCT07333742 ·Status: COMPLETED ·Phase: PHASE1
-
Trial to Evaluate the Efficacy and Safety of Gemigliptin Compared With Placebo Added on Insulin Alone or on Insulin in Combination With Metformin in Type 2 DM (ZEUS II Study)
NCT02831361 ·Status: COMPLETED ·Phase: PHASE3
-
A Study to Evaluate the Efficacy and Safety of Gemigliptin in Type 2 Diabetes Who Have Inadequate GlycemIc Control With Dapagliflozin and Metformin (SOLUTION Study)
NCT03842267 ·Status: COMPLETED ·Phase: PHASE3
-
Pharmacokinetic Drug Interaction Study Between Gemigliptin and Glimepiride in Healthy Male Subjects
NCT01768455 ·Status: COMPLETED ·Phase: PHASE1
-
BE Study of the Combinations of Gemigliptin/Metformin HCl Extended Release 50/1000mg(25/500mg x 2 Tablets) in Comparison to Each Component Administered Alone
NCT03355014 ·Status: COMPLETED ·Phase: PHASE1
-
Food-effect Bioavailability of Fixed Dose Combination Zemimet® SR Tab. 50/1000 mg Under Fed and Fasting Conditions
NCT04070794 ·Status: UNKNOWN ·Phase: PHASE1
-
Observational Study of Triple Combination Therapy of Zemidapa Tab. and Metformin in Type 2 Diabetes Mellitus Patients
NCT06495281 ·Status: COMPLETED
-
Bioequivalence Study of Empagliflozin And Linagliptin Tablets in Healthy Chinese Subjects
NCT05956522 ·Status: COMPLETED ·Phase: PHASE1
-
Clinical Trial to Evaluate Safety and pK Profile of Metformin Glycinate in Healthy Volunteers
NCT01560481 ·Status: COMPLETED ·Phase: PHASE1
-
Effect of Liraglutide or Glimepiride Added to Metformin on Blood Glucose Control in Subjects With Type 2 Diabetes
NCT00614120 ·Status: COMPLETED ·Phase: PHASE3
-
Pharmacokinetics of Fixed Dose Combination (FDC) Tablets of Linagliptin /Metformin
NCT01540487 ·Status: COMPLETED ·Phase: PHASE1
-
Study of Metabolic and Haemodynamic Effects of Metformin and Glimepiride in Patients With Type 2 Diabetes Mellitus
NCT01509001 ·Status: COMPLETED ·Phase: PHASE4