MedTrace Logo

Effect of Interventions on the Progression of Knee Osteoarthritis

NCT02178137 · Status: COMPLETED · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 322

Last updated 2018-03-01

No results posted yet for this study

Summary

There has been intensive search for a substance that can have disease-modifying activity for osteoarthritis. A number of medications have been reported to be of benefit on slowing progression of knee OA. This trial will be the first head to head comparison of these medications.

Patients aged between age 40 to 65 will be enrolled. Patients will be assessed clinically using two scoring systems, the WOMAC index for knee arthritis and the SF 36 for overall physical and mental health. The knee X rays will be assessed on Kellgren and Lawrence grading and will also be measured for joint space narrowing at follow up. The response to arthritis medications on slowing down cartilage loss will be measured biochemically with COMP levels.

Conditions

  • Osteo Arthritis of the Knees

Interventions

DRUG

Diacerien

DRUG

Glucosamine/Chondroitin

DRUG

Placebo

Sponsors & Collaborators

  • Indus Hospital and Health Network

    lead OTHER

Principal Investigators

  • Mansoor A Khan, MBBS · The Indus Hospital

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Model
PARALLEL

Eligibility

Min Age
40 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2014-06-30
Primary Completion
2017-09-30
Completion
2017-10-31

Countries

  • Pakistan

Study Locations

More Related Trials

Entities

Drugs

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02178137 on ClinicalTrials.gov