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Quantitative Determination of Brain Water Content in Patients During and After Hepatic Encepalopathy

NCT02177708 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 45

Last updated 2014-06-30

No results posted yet for this study

Summary

There is increasing evidence that the pathophysiology of hepatic encephalopathy (HE) is tightly associated with low-grade cerebral edema. Uptake of ammonia in astrocytes leads to osmotic swelling caused by glutamine formation. Previous studies were performed in covert HE patients or used indirect methods.

Methods: The investigators wish to describes quantitative measurement of localized water content using MRI water mapping in a cohort of patients with cirrhosis during an episode of overt HE type C and again after recovery. Furthermore patients with cirrhosis and no history of HE and healthy subjects will be investigated as controls.

Conditions

  • Hepatic Encephalopathy

Sponsors & Collaborators

  • University of Aarhus

    lead OTHER

Principal Investigators

  • Gitte Dam, MD, Phd · Aarhus University Hospital

Eligibility

Min Age
18 Years
Max Age
75 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2014-01-31
Primary Completion
2015-06-30
Completion
2015-12-31

Countries

  • Denmark

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02177708 on ClinicalTrials.gov