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Cortical Representation of Hyperalgesia Induced by Nerve Growth Factor

NCT02159170 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 20

Last updated 2015-01-16

No results posted yet for this study

Summary

Intraepidermal injection of nerve growth factor results in a non-inflammatory hyperalgesia for thermal and mechanical stimuli. This hyperalgesia is similar to the pathological ailments of patients with neuropathic pain. The mechanisms of the cognitive modulation of pain and hyperalgesia are not yet understood in this group of patients. The investigators plan to use NGF injection as a model of non-inflammatory neuropathic pain in healthy subjects to investigate the underlying neuronal mechanisms of this hyperalgesia using functional magnetic resonance imaging and resting state network analysis.

Conditions

  • Non-inflammatory Neuropathic Pain
  • Healthy Subjects

Interventions

BIOLOGICAL

NGF injection

single injection of NGF into the volar forearm / single injection of NaCl into the volar forearm

Sponsors & Collaborators

  • Heidelberg University

    collaborator OTHER

  • Prof Herta Flor

    lead OTHER

Principal Investigators

  • Herta Flor, PhD · Medical Faculty Mannheim, Heidelberg University

Study Design

Allocation
NA
Purpose
BASIC_SCIENCE
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Max Age
60 Years
Sex
MALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2014-03-31
Primary Completion
2014-12-31
Completion
2014-12-31

Countries

  • Germany

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02159170 on ClinicalTrials.gov