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Evolution of Molecular Biomarkers in Acute Heart Failure Induced by Shock

NCT02141607 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 70

Last updated 2018-06-15

No results posted yet for this study

Summary

The relationship between shock, ischemia and reperfusion (I/R) injury, hemodynamic instability, systemic inflammatory response syndrome and multiorgan failure has been extensively investigated, but there is no consensus on the trigger mechanisms of tissue injury at the molecular level.

Current therapies are targeted to reduce symptoms of shock and multiorgan damage but they are unable to act at the "beginning of the cascade", because of the lack of a model explaining the molecular basis of shock induced tissue injury and ensuing organ damage.

The present observational study is aimed at identifying the molecular triggers of acute heart failure (HF) induced by shock and to identify inflammatory mediators and markers that are activated in shock, with a particular emphasis on the role of uncontrolled proteolytic activity.

Conditions

  • Acute Heart Failure
  • Shock

Sponsors & Collaborators

  • Seventh Framework Programme

    collaborator OTHER

  • Shockomics Consortium

    lead NETWORK

Principal Investigators

  • Giuseppe Baselli, MS · Politecnico di Milano

Eligibility

Min Age
18 Years
Max Age
100 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2014-10-31
Primary Completion
2016-06-30
Completion
2017-09-30

Countries

  • Belgium
  • Spain
  • Switzerland

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02141607 on ClinicalTrials.gov