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The Study of Eustachian Tube Dysfunction and Laryngopharyngeal Reflux

NCT02123498 · Status: WITHDRAWN · Phase: PHASE4 · Type: INTERVENTIONAL

Last updated 2016-09-26

No results posted yet for this study

Summary

The purpose of this study is to investigate the relationship between ear fullness, pressure, and/or pain and laryngopharyngeal reflux, in order to focus medical therapy and improve therapeutic outcomes in this patient population.

Conditions

  • Eustachian Tube Dysfunction
  • Laryngopharyngeal Reflux

Interventions

DRUG

Omeprazole

40mg, to be taken once daily by mouth, 30-60 minutes before meals, for at least 6 weeks

DRUG

Ranitidine

300mg, to be taken once daily by mouth, before bedtime, for at least 6 weeks

DRUG

Pantoprazole

40mg, to be taken twice daily by mouth, 30-60 minutes before meals, for at least 6 weeks. (Alternative intervention if participant cannot tolerate omeprazole, is on an anticoagulant medication, or if on medication contraindicated for omeprazole and ranitidine)

PROCEDURE

24-Hour Diagnostic pH-Probe Test

Participants will undergo a routine clinical 24-hour diagnostic pH-probe test to assess quantitative measures for laryngopharyngeal reflux.

PROCEDURE

Laryngoscopy

Participants will undergo routine clinical laryngoscopy to assess presence of laryngopharyngeal reflux.

Sponsors & Collaborators

  • Loma Linda University

    lead OTHER

Principal Investigators

  • Helen X Xu, MD · Loma Linda University Otolaryngology Department

Study Design

Allocation
NA
Purpose
TREATMENT
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Primary Completion
2015-05-31

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02123498 on ClinicalTrials.gov