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Von Willebrand Factor to Predict Postoperative Outcome

NCT02118545 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 133

Last updated 2016-03-08

No results posted yet for this study

Summary

vWF is stored in weibel-palade-bodies of endothelial cells as well as alpha-granula of platelets and is released upon their activation. Endothelial cell dysfunction as well as platelet activation often occur in liver disease and portal hypertension, which may lead to an increase in circulating vWF levels. Indeed, multiple studies have reported that liver disease is associated with increased circulating vWF- antigen (vWF-Ag). Furthermore, increased circulating vWF -Ag Levels have been shown to be associated with increased mortality rates in patients with chronic liver disease. Within a prospective evaluation cohort, the investigators were able to document that patients with increased vWF-Ag levels prior to liver resection suffered from an increased incidence of postoperative liver dysfunction and morbidity. Within this prospective multicenter validation study, the investigators now aim to prospectively validate that circulating vWF-Ag prior to liver resection is a valuable marker to predict postoperative clinical outcome.

Conditions

  • Liver Dysfunction
  • Morbidity
  • Mortality
  • Hospitalisation

Sponsors & Collaborators

  • Medical University of Vienna

    lead OTHER

Principal Investigators

  • Patrick Starlinger, MD, PhD · Medical University Vienna

  • Thomas Gruenberger, MD · Rudolf Foundation Clinic

  • Stefan Stättner, MD · Paracelsus Medical University

  • Guido Beldi, MD · University of Bern

Eligibility

Min Age
18 Years
Max Age
85 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2014-04-30
Primary Completion
2016-02-29

Countries

  • Austria
  • Switzerland

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02118545 on ClinicalTrials.gov