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Bisphosphonates Effects On Alveolar Bone Among Osteoporotic Women

NCT02115490 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 60

Last updated 2015-09-29

No results posted yet for this study

Summary

Osteoporosis is a public health problem. It is a skeletal disease being treated by Bisphosphonates as the first choice medication. The effects of these drugs were investigated for periodontal disease treatment both locally and systemically. However, it is very important to know their indirect effects on alveolar bone (i.e. their effects when used for treating osteoporosis). So, in this study, alternations that involve the alveolar bone when osteoporotic women use bisphosphonates will be studied radiologically using cone-beam CT and digital panoramic radiography. The goal is to provide dentists with information about changes in the characterization of the alveolar bone among these women. This is important for both periodontology and implantology. Maxillary and mandibular bone structural characterization among osteoporotic women had not been studied before. Furthermore, in an opposite direction, dental radiographs may aid in detecting osteoporosis.

Osteoporotic women, under bisphosphonates therapy or not, will be invited to participate in this study. In addition, osteopenic and normal women regarding bone fragility will be included too, for comparison purposes. Panoramic radiographs will be taken. In addition, women under bisphosphonates for 6 months or more will be scanned by Cone -beam CT as it can give an idea about bone histomorphometry with a low radiation dose.

Conditions

Interventions

DRUG

Bisphosphonates

Sponsors & Collaborators

  • Damascus University

    lead OTHER

Principal Investigators

  • Imad Barngkgei, DDS MSc · PhD student, Department of Oral Medicine, University of Damascus Dental School, Damascus

  • Iyad Al-Haffar, DDS MSc PhD · Associate Professor of Oral Medicine, Department of Oral Medicine, University of Damascus Dental School, Damascus

  • Razan Khattab, DDS MSc PhD · Professor of Periodontology, Department of Periodontology, University of Damascus Dental School, Damascus, SYRIA

Eligibility

Min Age
45 Years
Max Age
75 Years
Sex
FEMALE
Healthy Volunteers
No

Timeline & Regulatory

Start
2014-04-30
Primary Completion
2015-08-31
Completion
2015-09-30

Countries

  • Syria

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02115490 on ClinicalTrials.gov