MedTrace Logo

Platelets in Liver Regeneration

NCT02113059 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 40

Last updated 2016-11-07

No results posted yet for this study

Summary

The most relevant factor predicting morbidity and mortality after liver resections is the ability of the remnant liver to regenerate. The investigators recently demonstrated that serotonin and thrombospondin-1, two growth factors abundantly stored in platelets, seem to play a critical role in liver regeneration of patients after liver resection. The investigators now aim to gain more precise insight concerning the relevance of platelets and platelet derived growth factors in liver regeneration in humans. The investigators will focus on specific alpha-granula release as a key regulator of postoperative LR. Using peri- and intraoperative blood and tissue samples, platelet adhesion, granula release and induction of gene expression known to be involved in liver regeneration form experimental studies will be analyzed. This study should allow the investigators to verify observations from preclinical models and evaluate their relevance in the human setting. Furthermore, this might enable the investigators to identify new therapeutic targets.

Conditions

  • Liver Regeneration

Sponsors & Collaborators

  • Medical University of Vienna

    lead OTHER

Principal Investigators

  • Patrick Starlinger, MD, PhD · Medical University Vienna

  • Alice Assinger, PhD · Medical University Vienna

Eligibility

Min Age
18 Years
Max Age
85 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2012-11-30
Primary Completion
2017-04-30

Countries

  • Austria

Study Locations

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02113059 on ClinicalTrials.gov