Optimising Anterior Pallidal Deep Brain Stimulation for Tourette's Syndrome

Summary

The motor tics associated with Tourette's syndrome may be reduced with deep brain stimulation of the anterior globus pallidus. The best area within this brain region and the best stimulation device settings are currently unknown. This is a study in which deep versus superficial electrode contact positions and two different amplitudes of stimulation are compared under scientific conditions. The hypothesis is that one contact position/stimulation amplitude combination will provide a better outcome than the others. Each study participant receives each of four different anatomical position/stimulation amplitude setting combinations over a 12 month period in randomized order followed by a 6-month period of trial-and-error device programming to optimize control of motor tics. Motor tics, potential side effects, daily functioning and quality of life are assessed at the end of each trial stimulation period. At the end of the study, the study participant continues to have long-term deep brain stimulation treatment with whatever settings provide the most relief.

Conditions

• Tourette's Syndrome

Interventions

DEVICE

Deep brain stimulator ventral electrode up to 2 mA

DEVICE

Deep brain stimulator ventral electrode up to 3 mA

DEVICE

Deep brain stimulator dorsal electrode up to 2 mA

DEVICE

Deep brain stimulator dorsal electrode up to 3 mA

DEVICE

Deep brain stimulator empirical programming

Sponsors & Collaborators

• Sir Charles Gairdner Hospital

  collaborator OTHER

• Perron Institute for Neurological and Translational Science

  collaborator OTHER

• The University of Western Australia

  lead OTHER

Principal Investigators

• Christopher Lind, FRACS · The University of Western Australia

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

QUADRUPLE

Model

CROSSOVER

Eligibility

Min Age

14 Years

Max Age

60 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2013-03-31

Primary Completion

2021-05-14

Completion

2021-05-14

Countries

• Australia

Study Locations