MedTrace Logo

Gastro-oesophageal Reflux in Oligosymptomatic Patients With Dental Erosion

NCT02087345 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 500

Last updated 2021-03-30

No results posted yet for this study

Summary

Dental erosions, the chemical dissolution of enamel without bacterial involvement, are considered to be an established complication of gastroesophageal reflux disease (GERD) by the Montreal global consensus statement. Given the high prevalence of dental erosions and the absence of any pH-impedance data or medical management guidelines for GERD-associated dental erosions, reflux characteristics will be characterized using questionnaires, endoscopy and esophageal pH-impedance testing, in successive patients dental erosions referred by dentists for evaluation of GERD. For assessment of the role of additional factors besides H+ activity in the refluxate, a sample of gastric juice will be aspirated during endoscopy and frozen for analysis of pepsin and other proteases. Prognostic factors for progression of dental erosions will be determined by repeating the evaluation after chronic dosing with esomeprazole 20mg twice-daily, which is prescribed to all patients.

Conditions

  • Dental Erosion
  • Gastroesophageal Reflux

Sponsors & Collaborators

  • Brain-Gut Research Group

    lead OTHER

Principal Investigators

  • Clive Wilder-Smith, MD · Brain-Gut Reserach Group

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2018-12-15
Primary Completion
2022-12-31
Completion
2023-06-30

Countries

  • Switzerland

Study Locations

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02087345 on ClinicalTrials.gov