"LANK-2": Activated and Expanded NK Cell Immunotherapy Together With Salvage Chemotherapy in Children, Adolescents and Young Adults With Relapsed or Refractary Acute Leukemia
NCT02074657 · Status: COMPLETED · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 13
Last updated 2016-12-20
Summary
To determine safety profile of immunotherapy with natural killer cells and activated expanded (NKAEs) after salvage chemotherapy in children, adolescents and young adults with relapsed or refractary acute leukemia
Conditions
- Relapsed/Refractory Paediatric Acute Leukaemia
Interventions
- BIOLOGICAL
-
Activated and expanded natural killer cells (NKAEs)
Activated and expanded natural killer cells (NKAEs) from haploidentical donor
Sponsors & Collaborators
-
Hospital Universitario La Paz
lead OTHER
Principal Investigators
-
Antonio Pérez-Martínez, MD, PhD · Hospital Infantil Universitario La Paz
Study Design
- Allocation
- NA
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- SINGLE_GROUP
Eligibility
- Max Age
- 23 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2014-04-30
- Primary Completion
- 2016-09-30
- Completion
- 2016-09-30
Countries
- Spain
Study Locations
More Related Trials
-
Safety of Expanded Haploidentical Natural Killer Cells for Leukemia
NCT04327037 ·Status: COMPLETED ·Phase: PHASE1
-
BL22 Immunotoxin In Treating Young Patients With Relapsed or Refractory Acute Lymphoblastic Leukemia or Non-Hodgkin's Lymphoma
NCT00077493 ·Status: SUSPENDED ·Phase: PHASE1
-
Study of Talimogene Laherparepvec In Children With Advanced Non CNS Tumors
NCT02756845 ·Status: COMPLETED ·Phase: PHASE1
-
Mobilization by Plerixafor of Haematopoietic Stem Cells in Children
NCT01225419 ·Status: COMPLETED ·Phase: PHASE2
-
Trabectedin and Irinotecan for Refractory Pediatric Sarcomas
NCT02509234 ·Status: UNKNOWN
-
Phase I Clinical Trial of Anlotinib in Progressive, Recurrent, and Refractory Sarcoma in Children
NCT04659733 ·Status: UNKNOWN ·Phase: PHASE1
-
A Multi-Institution Study of TGFβ Imprinted, Ex Vivo Expanded Universal Donor NK Cell Infusions as Adoptive Immunotherapy in Combination With Gemcitabine and Docetaxel in Patients With Relapsed or Refractory Pediatric Bone and Soft Tissue
NCT05634369 ·Status: RECRUITING ·Phase: PHASE1/PHASE2
-
A Combined Study in Pediatric Cancer Patients for Dose Ranging and Efficacy/Safety of Plerixafor Plus Standard Regimens for Mobilization Versus Standard Regimens Alone
NCT01288573 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
Therapy to Treat Ewing's Sarcoma, Rhabdomyosarcoma or Neuroblastoma
NCT00923351 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
A Study of Lenvatinib (MK-7902) in Pediatric Participants With Relapsed or Refractory Solid Malignancies (MK-7902-013/E7080)
NCT04447755 ·Status: COMPLETED ·Phase: PHASE2
-
Vaccine Therapy and Interleukin-2 in Treating Young Patients With Relapsed or Refractory Ewing's Sarcoma or Neuroblastoma
NCT00101309 ·Status: UNKNOWN ·Phase: PHASE1
-
Pilot Study of Redirected Haploidentical Natural Killer Cell Infusions for B-Lineage Acute Lymphoblastic Leukemia
NCT01974479 ·Status: SUSPENDED ·Phase: PHASE1
-
CH14.18 1021 Antibody and IL2 After Haplo SCT in Children With Relapsed Neuroblastoma
NCT02258815 ·Status: COMPLETED ·Phase: PHASE2
-
Clinical Trial of GAIA-102 for Refractory/Relapse Neuroblastomas and Other Malignant Pediatric Solid Tumors
NCT05608148 ·Status: RECRUITING ·Phase: PHASE1
-
Pulmonary Function at Presentation and Follow-up in Hemato-Oncology 3-7 Years Old Children
NCT00552825 ·Status: COMPLETED
-
A Study of LY2940680 in Pediatric Medulloblastoma or Rhabdomyosarcoma
NCT01697514 ·Status: WITHDRAWN ·Phase: PHASE1
-
A Phase I Dose Finding and Safety Study of Oral LDE225 in Children and a Phase II Portion to Assess Preliminary Efficacy in Recurrent or Refractory MB
NCT01125800 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, Immunogenicity, and Preliminary Efficacy of Atezolizumab (Anti-Programmed Death-Ligand 1 [PD-L1] Antibody) in Pediatric and Young Adult Participants With Solid Tumors
NCT02541604 ·Status: TERMINATED ·Phase: PHASE1/PHASE2
-
Treatment of Pediatric Very High-risk Acute Lymphoblastic Leukemia in Korea
NCT06257394 ·Status: RECRUITING ·Phase: PHASE2
-
Phase II Study of Everolimus in Children and Adolescents With Refractory or Relapsed Rhabdomyosarcoma and Other Soft Tissue Sarcomas
NCT01216839 ·Status: UNKNOWN ·Phase: PHASE2
-
Qarziba for Patients in Relapsed/Refractory High-grade Osteosarcoma
NCT05558280 ·Status: SUSPENDED ·Phase: PHASE2
-
Study of Adoptive Immunotherapy in Relapsed and Non-resectable Sarcomas After Multimodal Treatment.
NCT03782363 ·Status: WITHDRAWN ·Phase: PHASE1
-
Phase II Study of Everolimus in Children and Adolescents With Refractory or Relapsed Osteosarcoma
NCT01216826 ·Status: UNKNOWN ·Phase: PHASE2
-
Adipokines as Predictors of the Metabolic Syndrome in ALL Survivors
NCT00566566 ·Status: UNKNOWN
-
A Pilot Study of Autologous T-Cell Transplantation With Vaccine Driven Expansion of Anti-Tumor Effectors After Cytoreductive Therapy in Metastatic Pediatric Sarcomas
NCT00001566 ·Status: COMPLETED ·Phase: PHASE2