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Efficacy of Simvastatin for the Treatment of COPD

NCT02070133 · Status: COMPLETED · Phase: PHASE3 · Type: INTERVENTIONAL · Enrollment: 18

Last updated 2014-02-25

No results posted yet for this study

Summary

To evaluate in patients with stable Chronic Obstructive Pulmonary Disease (COPD) the efficacy of statins (simvastatin) on: (1) endothelial function; (2) systemic inflammation; (3)BODE (B: body mass , O: bronchial obstruction, D: dyspnea and, E: exercise tolerance) index; (4) Uric acid; and, (5)vascular growth factors. Design: a 12 weeks randomized (1:1), double-blind, placebo control study. Population: 18 males with stable COPD between 40-80 years of age, exsmokers, with Forced expiratory volume in one second (FEV1) between 30 and 80% predicted post-bronchodilation.

Conditions

Interventions

DRUG

Simvastatin

Simvastatin 40 mg once a day during 12 weeks

DRUG

Placebo

Placebo once a day during 12 weeks

Sponsors & Collaborators

  • Fundació d'investigació Sanitària de les Illes Balears

    collaborator OTHER_GOV

  • Cimera

    collaborator NETWORK

  • Hospital Universitari Son Dureta

    lead OTHER

Principal Investigators

  • Ernest Sala, MD · Hospital Son Espases, Palma Mallorca

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
40 Years
Max Age
80 Years
Sex
MALE
Healthy Volunteers
No

Timeline & Regulatory

Start
2009-05-31
Primary Completion
2013-03-31
Completion
2013-05-31

Countries

  • Spain

Study Locations

More Related Trials

Entities

Drugs
Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02070133 on ClinicalTrials.gov