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Antitussive Effect of a Naturally Flavored Syrup Containing Diphenhydramine, Compared With Dextromethorphan and Placebo

NCT02062710 · Status: COMPLETED · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 22

Last updated 2018-02-28

Study results available
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Summary

The purpose of this study is to evaluate the antitussive (cough-suppressing) effects of two liquid medications: a combination of diphenhydramine and phenylephrine in a naturally cocoa flavoring, and, dextromethorphan syrup, compared with placebo.

Conditions

  • Cough Reflex Sensitivity

Interventions

DRUG

diphenhydramine/phenylephrine/cocoa; dextromethorophan; placebo

diphenhydramine 25 mg and phenylephrine 10 mg; dextromethorphan 30 mg; placebo.

DRUG

diphenhydramine/phenylephrine/cocoa; placebo; dextromethorphan

diphenhydramine 25 mg and phenylephrine 10 mg; placebo; dextromethorphan 30 mg.

DRUG

dextromethorphan; diphenhydramine/phenylephrine/cocoa; placebo

dextromethorphan 30 mg; diphenhydramine 25 mg and phenylephrine 10 mg; placebo

DRUG

dextromethorophan; placebo; diphenhydramine/phenylephrine/cocoa

dextromethorphan 30 mg; placebo; diphenhydramine 25 mg and phenylephrine 10 mg

DRUG

placebo; diphenhydramine/phenylephrine/cocoa; dextromethorphan

placebo; diphenhydramine 25 mg and phenylephrine 10 mg; dextromethorphan 30 mg

DRUG

placebo; dextromethorphan; diphenhydramine/phenylephrine/cocoa

placebo; dextromethorphan 30 mg; diphenhydramine 25 mg and phenylephrine 10 mg

Sponsors & Collaborators

  • Montefiore Medical Center

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2014-01-31
Primary Completion
2014-06-30
Completion
2014-06-30

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02062710 on ClinicalTrials.gov