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The Mechanisms of Diameter Changes in Retinal Vessels During Hypoxia

NCT02059018 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 20

Last updated 2015-08-19

No results posted yet for this study

Summary

The primary objective is to study if a stimulation of nitric oxide and/or prostaglandin affect the diameter changes of retinal vessels during hypoxia. Diameter changes are studied using the Dynamic Vessel Analyzer.

Conditions

  • Retinal Hypoxia

Interventions

DRUG

COX-inhibitor

Administration of 1 drop voltaren 45 minutes before recordings of diameter changes of retinal vessels are initiated

DRUG

Nitroglycerin

Oral administration of tablet nitroglycerin 0,5mg 5 minutes before recordings of diameter changes of retinal vessels are initiated

DRUG

COX-inhibitor + Nitroglycerin

Combination of COX-inhibitor and nitroglycerin interventions.

Sponsors & Collaborators

  • University of Aarhus

    lead OTHER

Principal Investigators

  • Line Pedersen, MD · Aarhus University Hospital

  • Musa Kaya, stud.med · Aarhus University Hospital

Study Design

Allocation
NON_RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Model
CROSSOVER

Eligibility

Min Age
20 Years
Max Age
60 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2014-02-28
Primary Completion
2015-02-28
Completion
2015-08-31

Countries

  • Denmark

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02059018 on ClinicalTrials.gov