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Treatment of Cerebral Radiation Necrosis (CRN) With Nerve Growth Factor (NGF)

NCT02032147 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 30

Last updated 2014-01-09

No results posted yet for this study

Summary

Cerebral radiation necrosis (CRN) is a well-documented late complication of radiation therapy for cancers, and may have a devastating effect on the patient's quality of life (QOL). However,CRN was once regarded as a progressive and irreversible disease, no standard therapy has been suggested for CRN. In our clinical practice, we have used nerve growth factor(NGF) to treat CRN, and found that GM1 can successfully reverse CRN. A case report has been published in Journal of Clinical Oncology (JCO) in 2011. So we carried out this prospective study to test the efficacy of NGF for CRN.

Conditions

  • Cerebral Necrosis
  • Nashopharyngeal Cancer
  • Nerve Growth Factor

Interventions

DRUG

NGF group

This group will be treated with NGF 18u per day im for 60 days

Sponsors & Collaborators

  • Fudan University

    lead OTHER

Eligibility

Min Age
18 Years
Max Age
70 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2009-03-31
Primary Completion
2012-10-31
Completion
2012-10-31

Countries

  • China

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02032147 on ClinicalTrials.gov