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Local 5-Fluorouracil Injection for the Treatment of Chalazia: A Prospective, Comparative Study

NCT02025023 · Status: RECRUITING · Phase: PHASE3 · Type: INTERVENTIONAL · Enrollment: 120

Last updated 2020-02-06

No results posted yet for this study

Summary

Local injection of 5-fluorouracil into a chalazion (stye) is as effective as local injection of triamcinolone (steroid) and incision and curettage for treatment of chalazia.

Conditions

  • Chalazion

Interventions

DRUG

5-fluorouracil Injection

If the chalazion is present at follow-up visit, another injection of 5-FU will be given.

DRUG

Triamcinolone Acetonide

If chalazion present at follow-up, another Triamcinolone injection will be done.

PROCEDURE

Incision and Curettage

If chalazion present at follow-up visit, patient will be randomized to receive local injection of either triamcinolone, 5-FU, or triamcinolone/5-FU mixture.

DRUG

Triamcinolone Acetonide/5-fluorouracil mixture

If chalazion persists at follow-up visit, another injection of triamcinolone/5-FU mixture will be done.

Sponsors & Collaborators

Principal Investigators

  • Matthew M Zhang, MD · University of Washington Eye Institute

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2013-12-31
Primary Completion
2025-07-31
Completion
2026-07-31
FDA Drug
Yes

Countries

  • United States

Study Locations

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Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02025023 on ClinicalTrials.gov