Efficacy of Exposure and Response Prevention(ERP) and SSRIs in Chinese OCD Patients

Summary

The purpose of this study is to evaluate the efficiency of SSRIs（Selective Serotonin Reuptake Inhibitor） ,ERP（Exposure and Response Prevention） and the combination of the two therapies for OCD(Obsessive-Compulsive Disorder) patients ,at the same time, to find out the biological or psychological predictors of treatment response in Chinese population.

Conditions

• Obsessive-Compulsive Disorder
• Anxiety Disorders
• Mental Disorders

Interventions

DRUG

Fluoxetine

The dosage depends on clinician's judgement ,but not over the maximum tolerated dosage.

DRUG

Sertraline

The dosage depends on clinician's judgement ,but not over the maximum tolerated dosage.

DRUG

Paroxetine

The dosage depends on clinician's judgement ,but not over the maximum tolerated dosage.

DRUG

Citalopram

The dosage depends on clinician's judgement ,but not over the maximum tolerated dosage.

DRUG

Fluvoxamine

The dosage depends on clinician's judgement ,but not over the maximum tolerated dosage.

BEHAVIORAL

Exposure and Response Prevention

8 exposure and response prevention (ERP) sessions,once a week

Sponsors & Collaborators

• Shanghai Municipal Science and Technology Commission

  collaborator OTHER_GOV

• Shanghai Jiao Tong University School of Medicine

  collaborator OTHER

• Shanghai Mental Health Center

  lead OTHER

Principal Investigators

• Zhen Wang, Ph.D, M.D · Shanghai Mental Health Center

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Model

CROSSOVER

Eligibility

Min Age

16 Years

Max Age

65 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2014-01-31

Primary Completion

2017-11-18

Completion

2018-03-13

Countries

• China

Study Locations