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Effects of Etomidate on Postoperative Circadian Rhythm Changes of Salivary Cortisol in Children

NCT02013986 · Status: UNKNOWN · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 30

Last updated 2013-12-17

No results posted yet for this study

Summary

Etomidate is an unique drug used for induction of general anesthesia and sedation. Adrenal cortical inhibition by etomidate has received much attention. However wether the circadian rhythm and pulse secretion pattern of cortisol in children are the same as that in adults is not known. Moreover, the effect of etomidate on circadian rhythm changes and clinical outcomes has never been carefully studied in children undergoing surgery. Our hypothesis is that etomidate can relieve the changes of circadian rhythm of salivary cortisol in children for 24-48 hours，and this does not make clinical outcomes worse postoperatively.

Conditions

  • Congenital Hydronephrosis
  • Congenital Choledochal Cyst
  • Fracture

Interventions

DRUG

etomidate

0.3mg/kg IV only once during induction of general anesthesia

DRUG

midazolam

midazolam 0.1mg/kg IV only once before using of etomidate/propofol during induction of general anesthesia

DRUG

propofol

2mg/kg IV only once during induction of general anesthesia

Sponsors & Collaborators

  • Du yi

    lead OTHER

Principal Investigators

  • Wng Y Wei, professor · Shanghai Jiao Tong University School of Medicine

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Model
PARALLEL

Eligibility

Min Age
3 Years
Max Age
12 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2013-09-30
Primary Completion
2014-06-30
Completion
2014-08-31

Countries

  • China

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02013986 on ClinicalTrials.gov