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[11C]Donepezil PET For Imaging The Autonomous Nervous System In Parkinsons Disease

NCT02012595 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 24

Last updated 2015-06-02

No results posted yet for this study

Summary

AIM: Investigate wether there are differences in the parasympathetic nervous system in Parkinsons patients compared to controls.

MATERIALS AND METHODS: We use the tracer \[11C\]donepezil to image the parasympathetic nervous system. The Investigators will include 20 Parkinsons patients and 20 healthy controls aged 40-80 in our study. The participants will receive a careful medical examination, including a neurological examination, as part of the inclusion process. The subjects also have an MRI scan of the brain. Then PET/CT scans with \[11C\]donepezil are conducted - once for the upper abdominal region and once for the head region. For evaluating the function of the parasympathetic nervous system gastric emptying time, heart rate variability and salivary flow will be measured. These measureless will be correlated to the PET findings.

PERSPECTIVES: The study will potentially result in the development of a PET ligand for imaging the parasympathetic nervous system. This will have applications for research in Parkinson's disease, diabetes, heart disease and other disorders, in which the autonomic nervous system is involved

Conditions

Interventions

OTHER

[11C]donepezil PET

Positon Emission Tomography (PET) imaging of acetylcholinesterase using the ligand \[11C\]donepezil

Sponsors & Collaborators

  • Lundbeck Foundation

    collaborator OTHER

  • Jascha Fonden

    collaborator OTHER

  • Fonden af 2. Juli 1984 til bekæmpelse af Parkinsons Sygdom, Denmark

    collaborator OTHER

  • Per Borghammer

    lead OTHER

Principal Investigators

  • Per Borghammer, MD, PhD,DMSc · Dept. of Nuclear Medicine & PET Center, Aarhus University Hospital, Aarhus, Denmark

Eligibility

Min Age
40 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2013-10-31
Primary Completion
2015-01-31
Completion
2015-01-31

Countries

  • Denmark

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02012595 on ClinicalTrials.gov