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Statin and Angiotensin-converting Enzyme Inhibitor on Symptoms in Patients With SCAD

NCT02008786 · Status: TERMINATED · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 18

Last updated 2024-03-15

No results posted yet for this study

Summary

An emerging cause of heart attack in young women is a dissection (or tear) in the coronary arteries. Many of these young women continue to have chest pain long after the tear has healed and this is thought to be due to problems with their small blood vessels of the heart (or microcirculation). We want to determine whether commonly used medications for coronary artery disease including statins (for cholesterol) and angiotensin-converting enzyme inhibitors (for blood pressure) reduce chest pain and improve small vessel function in these patients.

Conditions

  • Coronary Artery Dissection, Spontaneous

Interventions

DRUG

ramipril

5-10mg (starting dose 5mg titrating up to 10mg if tolerated after 1 week)

DRUG

rosuvastatin

10-20mg (suggested dose 10mg for Asians, 20mg for everyone else)

DRUG

placebo

Placebo

Sponsors & Collaborators

  • Cardiology Research UBC

    lead OTHER

Principal Investigators

  • Tara Sedlak, MD · University of British Columbia

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Model
CROSSOVER

Eligibility

Sex
FEMALE
Healthy Volunteers
No

Timeline & Regulatory

Start
2014-06-30
Primary Completion
2019-09-13
Completion
2019-09-13

Countries

  • Canada

Study Locations

More Related Trials

Entities

Drugs

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02008786 on ClinicalTrials.gov