Trial Outcomes & Findings for Pre-arrival Instructions Effect on Bystander Cardiopulmonary Resuscitation (CPR). (NCT NCT02007499)
NCT ID: NCT02007499
Last Updated: 2026-04-07
Results Overview
The overall goal of this study is to determine the rate of bystander Cardiopulmonary Resuscitation (CPR) before and after implementation of Cardiopulmonary Resuscitation (CPR) pre-arrival instructions program in Milwaukee County
COMPLETED
274 participants
Up to 2 years prior to intervention and up to 2 years post intervention
2026-04-07
Participant Flow
Subjects were \> 21 years with non-EMS witnessed OHCA of presumed cardiac origin. Cases of obvious irreversible death, trauma-related OHCA, known DNR, or in which EMS or other healthcare provider CPR was performed were excluded Total 344 OHCA in 2 communities 20 \< 21 years, 50 non-cardiac arrest, 75 CPR not specified, so 199 met inclusion criteria
Analyze how implementation of CPR pre-arrival instruction affected probability of receiving bystander CPR, to determine rate of bystander CPR before and after implementation of instructions, explore relationship to age, gender, location of arrest on survival to hospital discharge. Total 344 OHCA in 2 communities, 20 \< 21 year, 50 non-cardiac arrest
Participant milestones
| Measure |
Pre-arrival CPR Instruction Before Intervention in Community 1
Pre-arrival Cardiopulmonary Resuscitation (CPR) instruction for bystander Before Intervention Group in Community 1 was 34
|
Pre-arrival CPR Instruction After Intervention in Community 1
Pre-arrival Cardiopulmonary Resuscitation (CPR) instruction for bystander After Intervention Group in Community 1 was 46
|
Pre-arrival CPR Instruction Before Intervention in Community 2
Pre-arrival Cardiopulmonary Resuscitation (CPR) instruction for bystander Before Intervention Group in Community 2 was 76
|
Pre-arrival CPR Instruction After Intervention in Community 2
Pre-arrival Cardiopulmonary Resuscitation (CPR) instruction for bystander After Intervention Group in Community 2 was 43
|
|---|---|---|---|---|
|
Overall Study
STARTED
|
44
|
63
|
99
|
68
|
|
Overall Study
COMPLETED
|
34
|
46
|
76
|
43
|
|
Overall Study
NOT COMPLETED
|
10
|
17
|
23
|
25
|
Reasons for withdrawal
| Measure |
Pre-arrival CPR Instruction Before Intervention in Community 1
Pre-arrival Cardiopulmonary Resuscitation (CPR) instruction for bystander Before Intervention Group in Community 1 was 34
|
Pre-arrival CPR Instruction After Intervention in Community 1
Pre-arrival Cardiopulmonary Resuscitation (CPR) instruction for bystander After Intervention Group in Community 1 was 46
|
Pre-arrival CPR Instruction Before Intervention in Community 2
Pre-arrival Cardiopulmonary Resuscitation (CPR) instruction for bystander Before Intervention Group in Community 2 was 76
|
Pre-arrival CPR Instruction After Intervention in Community 2
Pre-arrival Cardiopulmonary Resuscitation (CPR) instruction for bystander After Intervention Group in Community 2 was 43
|
|---|---|---|---|---|
|
Overall Study
Protocol Violation
|
10
|
17
|
23
|
25
|
Baseline Characteristics
Pre-arrival Instructions Effect on Bystander Cardiopulmonary Resuscitation (CPR).
Baseline characteristics by cohort
| Measure |
Community 1 CPR Instruction Before
n=44 Participants
Pre-arrival Cardiopulmonary Resuscitation (CPR) instruction for bystander Before Intervention Group in Community
|
Community 1 CPR Instruction After
n=63 Participants
Pre-arrival Cardiopulmonary Resuscitation (CPR) instruction for bystander After Intervention Group in Community
|
Community 2 CPR Instruction Before
n=99 Participants
Pre-arrival Cardiopulmonary Resuscitation (CPR) instruction for bystander Before Intervention Group in Community
|
Community 2 CPR Instruction After
n=68 Participants
Pre-arrival Cardiopulmonary Resuscitation (CPR) instruction for bystander After Intervention Group in Community
|
Total
n=274 Participants
Total of all reporting groups
|
|---|---|---|---|---|---|
|
Age, Continuous
|
63.2 years
n=527 Participants
|
62.5 years
n=527 Participants
|
66.2 years
n=1054 Participants
|
65.5 years
n=157 Participants
|
64.7 years
n=86 Participants
|
|
Sex: Female, Male
Female
|
14 Participants
n=527 Participants
|
21 Participants
n=527 Participants
|
38 Participants
n=1054 Participants
|
24 Participants
n=157 Participants
|
97 Participants
n=86 Participants
|
|
Sex: Female, Male
Male
|
30 Participants
n=527 Participants
|
42 Participants
n=527 Participants
|
61 Participants
n=1054 Participants
|
44 Participants
n=157 Participants
|
177 Participants
n=86 Participants
|
|
Region of Enrollment
United States
|
44 participants
n=527 Participants
|
63 participants
n=527 Participants
|
99 participants
n=1054 Participants
|
68 participants
n=157 Participants
|
274 participants
n=86 Participants
|
PRIMARY outcome
Timeframe: Up to 2 years prior to intervention and up to 2 years post interventionThe overall goal of this study is to determine the rate of bystander Cardiopulmonary Resuscitation (CPR) before and after implementation of Cardiopulmonary Resuscitation (CPR) pre-arrival instructions program in Milwaukee County
Outcome measures
| Measure |
Community 1, Before
n=34 Participants
Community 1, the rate of bystander CPR before instructions
|
Community 1, After
n=46 Participants
Community 1, the rate of bystander CPR after instructions
|
Community 2, Before
n=76 Participants
Community 2, the rate of bystander CPR before instruction
|
Community 2, After
n=43 Participants
Community 2, the rate bystander CPR after instruction
|
|---|---|---|---|---|
|
Incidence of Bystander Cardiopulmonary Resuscitation (CPR) in Out of Hospital Cardiac Arrest (OHCA)
|
11 participants
Interval -15.0 to 21.0
|
19 participants
Interval -15.6 to 21.4
|
42 participants
Interval -15.4 to 49.5
|
25 participants
Interval -15.4 to 29.5
|
SECONDARY outcome
Timeframe: Up to 2 years prior to intervention and up to 2 years post interventionExplore any relationship to age and gender of the patient, location of arrest, time of year, and other indicators known to affect survival on the overall difference in patient discharge.
Outcome measures
| Measure |
Community 1, Before
n=34 Participants
Community 1, the rate of bystander CPR before instructions
|
Community 1, After
n=46 Participants
Community 1, the rate of bystander CPR after instructions
|
Community 2, Before
n=76 Participants
Community 2, the rate of bystander CPR before instruction
|
Community 2, After
n=43 Participants
Community 2, the rate bystander CPR after instruction
|
|---|---|---|---|---|
|
Survival to Hospital Discharge or to December, 31 2013 Whichever Comes First
|
11 Participants
|
19 Participants
|
42 Participants
|
25 Participants
|
Adverse Events
Community 1 Before
Community 1 After
Community 2 Before
Community 2 After
Serious adverse events
Adverse event data not reported
Other adverse events
Adverse event data not reported
Additional Information
Khalid A. A. Ateyyah
Taibah University, College of Medicine
Results disclosure agreements
- Principal investigator is a sponsor employee
- Publication restrictions are in place