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D-Dimer Determined Anticoagulation INTENSITY in Patients With Mechanical Valve Replacement

NCT01996657 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 772

Last updated 2017-06-26

Study results available
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Summary

The optimal intensity of oral anticoagulation in China patients undergoing mechanical valve replacements is still controversial due to the different risk profiles of thrombophilia and bleeding in Chinese patients. Elevated D-dimer could reflect a pro-thrombogenic or prothrombotic state, and thus might be used to decide the intensity of oral anticoagulation.

This study was to evaluate whether elevated D-dimer levels could help to determine the intensity of oral anticoagulation in patients with mechanical heart valve prostheses.

Conditions

  • Heart Valve Disease

Interventions

DRUG

Warfarin

Sponsors & Collaborators

  • Wuhan Asia Heart Hospital

    lead OTHER

Principal Investigators

  • zhang zhenlu, PH.D · Wuhan Asia Heart Hospital

  • Zhou xin, Doctor · Wuhan Asia Heart Hospital

  • liu ze jin, PH.D · Wuhan Asia Heart Hospital

Eligibility

Min Age
18 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2013-01-31
Primary Completion
2016-05-31
Completion
2016-06-30

Countries

  • China

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01996657 on ClinicalTrials.gov