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In Vivo Confocal Microscopy Study of Pigmented Conjunctival Lesions

NCT01993654 · Status: TERMINATED · Type: OBSERVATIONAL · Enrollment: 17

Last updated 2016-08-15

No results posted yet for this study

Summary

This study aims to validate the use of laser in vivo confocal microscopy as an early diagnostic and differentiation tool of pigmented conjunctival lesions, evaluate the efficacy of in vivo confocal microscopy for follow-up (as a visualizing tool) after tumor resection for early detection of tumor recurrence, and to evaluate the use of in vivo confocal microscopy in evaluation of response to treatment. The modified technique with Heidelberg Retina Tomography (HRT) confocal microscopy and anterior segment optical coherence tomography (OCT) are non-invasive, no-touch, imaging techniques that may help in differentiation of benign lesions like nevi or racial melanosis, from malignant lesions like primary acquired melanosis and malignant melanomas. The OCT will potentially allow to estimate tumor depth in vivo as preliminary studies have shown.

Conditions

  • Nevus
  • Racial Melanosis
  • Primary Acquired Melanosis
  • Conjunctival Malignant Melanoma

Interventions

PROCEDURE

HRT III with Non-Contact Cornea Rostock Module

Confocal imaging of the conjunctival lesion

Sponsors & Collaborators

  • M.D. Anderson Cancer Center

    collaborator OTHER

  • Wills Eye

    collaborator OTHER

  • Massachusetts Eye and Ear Infirmary

    lead OTHER

Principal Investigators

  • Pedram Hamrah, MD · Massachusetts Eye and Ear Infirmary

  • Carol Shields, MD · Wills Eye Hospital

  • Arman Mashayekhi, MD · Wills Eye Hospital

  • Bita Esmaeli, MA, MD · M.D. Anderson Cancer Center

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2011-09-30
Primary Completion
2015-07-31
Completion
2015-07-31

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01993654 on ClinicalTrials.gov