MedTrace Logo

DBS for Treatment Resistant Depression

NCT01983904 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 22

Last updated 2019-04-18

No results posted yet for this study

Summary

The purpose of this study is to examine the effects of sub-callosal cingulate (SCC) deep brain stimulation (DBS) in patients with treatment resistant depression (TRD).

The working hypotheses are that long pulse-width DBS applied to the SCC region will lead to improvements in TRD patients, and specific neuroimaging biomarkers will correlate with response to DBS; the functional recovery will be enhanced with concurrent cognitive behavioural therapy (CBT).

Conditions

  • Depressive Disorder, Treatment-Resistant

Interventions

DEVICE

deep brain stimulation with short & long pulse width

surgical implantation for bilateral electrodes and stimulation using short and long pulse width

Sponsors & Collaborators

  • University of Calgary

    lead OTHER

Principal Investigators

  • Zelma H Kiss, MD PhDFRCSC · University of Calgary, Department of Clinical Neurosciences

  • Rajamannar Ramasubbu, MD MRCP FRCP · University of Calgary, Department of Psychiatry

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Model
SINGLE_GROUP

Eligibility

Min Age
20 Years
Max Age
70 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2013-08-31
Primary Completion
2017-12-31
Completion
2018-03-31

Countries

  • Canada

Study Locations

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01983904 on ClinicalTrials.gov