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Dexamethasone for the Treatment of Established Postoperative Nausea and Vomiting

NCT01975727 · Status: TERMINATED · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 256

Last updated 2019-12-10

No results posted yet for this study

Summary

Postoperative nausea and vomiting (PONV) are frequent after surgery and anaesthesia. Dexamethasone is widely used as antiemetic for the prevention of PONV. Little is known about the efficacy of antiemetic drugs for the treatment of established PONV symptoms. No single randomised trial has been published so far that tests the efficacy of dexamethasone for the treatment of established PONV symptoms. In this trial the investigators want to test the antiemetic efficacy of three different doses of intravenous dexamethasone for the treatment of established PONV symptoms. In adjunct protocols of this study the investigators aim to establish a novel method to quantify the anti-nausea efficacy of an antiemetic drug, to study pharmacogenetics of PONV, and to further our understanding on the smoking status as a predictive factor of PONV.

Conditions

  • Postoperative Nausea and Vomiting
  • Vomiting

Interventions

DRUG

Placebo

Injection of placebo (saline 0.9%)

DRUG

Dexamethasone 3 mg

10 ml Seringue with Dexamethasone

DRUG

Dexamethasone 6 mg

10 ml Seringue with Dexamethasone

DRUG

Dexamethasone 12 mg

10 ml Seringue with Dexamethasone

Sponsors & Collaborators

  • Swiss National Science Foundation

    collaborator OTHER

  • University Hospital, Geneva

    lead OTHER

Principal Investigators

  • Martin R Tramèr, Prof. · University Hospitals of Geneva

  • Christoph Czarnetzki, MD · University Hospitals of Geneva

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2012-09-03
Primary Completion
2017-11-08
Completion
2017-11-09

Countries

  • Switzerland

Study Locations

More Related Trials

Entities

Drugs
Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01975727 on ClinicalTrials.gov