International Ovarian & Testicular Stromal Tumor Registry

Summary

Rare tumors are understudied, yet have the potential to shed light on vast areas of cancer research. Ovarian sex cord-stromal tumors, rare tumors of childhood and young adulthood, have recently been found to be associated with a lung cancer of early childhood called pleuropulmonary blastoma (PPB). The cause of these ovarian tumors is unknown. DICER1 mutations are seen in the majority of children with PPB. Research shows DICER1 mutations are also seen in some patients with ovarian tumors. Like PPB, ovarian stromal tumors are highly curable when found in early stage; however, later forms of the disease are aggressive and often fatal. The International Ovarian Stromal Tumor Registry collects clinical and biologic data to understand why these tumors occur and how to treat them. Current work involves the study of the role of DICER1 and miRNA expression in ovarian stromal tumors. Understanding the clinical history, predisposing factors and DICER1 and miRNA expression in these ovarian tumors of childhood will lead to targeted screening and risk stratification for evidence-based treatment and biologically rational therapies. These efforts will improve the lives of children by increasing survival and reducing late effects.

The specific goals of the International Ovarian and Testicular Stromal Tumor Registry are:

1. to understand risk factors by studying age, pathologic subtype, histopathologic features, tumor invasiveness, degree of differentiation, presence of metastasis
2. to collect information on personal and family history in order to refine the clinical characteristics of patients and families with and without germline DICER1 mutations and other genetic predisposing factors
3. to determine whether there is a pattern of gene expression or DNA alterations that correlate with predisposition to ovarian tumors, biologic behavior and clinical outcome
4. to determine optimal screening regimens
5. to use clinical data obtained through the Registry to refine treatment algorithms
6. to establish a collection of annotated biology specimens (tumor tissue and germline DNA) for future research

Conditions

• Ovarian Sex-cord Stromal Tumor
• Testicular Stromal Tumors
• Ovarian Small Cell Carcinoma

Sponsors & Collaborators

• Children's National Research Institute

  collaborator OTHER

• Dana-Farber Cancer Institute

  collaborator OTHER

• Washington University School of Medicine

  collaborator OTHER

• University of Texas Southwestern Medical Center

  collaborator OTHER

• M.D. Anderson Cancer Center

  collaborator OTHER

• Children's Hospital Colorado

  collaborator OTHER

• Rutgers University

  collaborator OTHER

• Massachusetts General Hospital

  collaborator OTHER

• Klinikum Dortmund Wirbelsäulenchirurgie

  collaborator OTHER

• ResourcePath, LLC

  collaborator UNKNOWN

• Allina Health System

  collaborator OTHER

• Phoenix Children's Hospital

  collaborator OTHER

• University of Cambridge

  collaborator OTHER

• Children's Hospitals and Clinics of Minnesota

  lead OTHER

Principal Investigators

• Kris Ann P Schultz, MD · Children's Minnesota

Eligibility

Min Age

0 Years

Max Age

100 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2011-12-08

Primary Completion

2028-12-31

Completion

2030-12-31

Countries

• United States

Study Locations